Levodopa responsiveness and white matter alterations in Parkinson's disease: A DTI-based study and brain network analysis: A cross-sectional study

作者全名："Du, Juncong; Zhou, Xuan; Liang, Yi; Zhao, Lili; Dai, Chengcheng; Zhong, Yuke; Liu, Hang; Liu, Guohui; Mo, Lijuan; Tan, Changhong; Liu, Xi; Chen, Lifen"

作者地址："[Du, Juncong; Zhou, Xuan; Liang, Yi; Zhao, Lili; Dai, Chengcheng; Zhong, Yuke; Liu, Hang; Liu, Guohui; Mo, Lijuan; Tan, Changhong; Liu, Xi; Chen, Lifen] Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Liu, X; Chen, LF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：BRAIN AND BEHAVIOR

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000889587000001

JCR分区：Q2

影响因子：3.1

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：brain network; levodopa responsiveness; Parkinson's disease; white matter

摘要："BackgroundPatients with Parkinson's disease (PD) present various responsiveness to levodopa, but the cause of such differences in levodopa responsiveness is unclear. Previous studies related the damage of brain white matter (WM) to levodopa responsiveness in PD patients, but no study investigated the relationship between the structural brain network change in PD patients and their levodopa responsiveness. MethodsPD patients were recruited and evaluated using the Unified Parkinson's Disease Rating Scale (UPDRS). Each patient received a diffusion tensor imaging (DTI) scan and an acute levodopa challenge test. The improvement rate of UPDRS-III was calculated. PD patients were grouped into irresponsive group (improvement rate < 30%) and responsive group (improvement rate >= 30%). Tract-based spatial statistics (TBSS), deterministic tracing (DT), region of interest (ROI) analysis, and automatic fiber identification (AFQ) analyses were performed. The structural brain network was also constructed and the topological parameters were calculated. ResultsFifty-four PD patients were included. TBSS identified significant differences in fractional anisotropy (FA) values in the corpus callosum and other regions of the brain. DT and ROI analysis of the corpus callosum found a significant difference in FA between the two groups. Graph theory analysis showed statistical differences in global efficiency, local efficiency, and characteristic path length. ConclusionPD patients with poor responsiveness to levodopa had WM damage in multiple brain areas, especially the corpus callosum, which might cause disruption of information integration of the structural brain network."

基金机构：National Natural Science Foundation of China; Natural Science Foundation of Chongqing; Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University; [81771391]; [82001367]; [cstc2021jcyj-msxmX0180]

基金资助正文："ACKNOWLEDGMENTS This study was supported by National Natural Science Foundation of China (grant number: 81771391, receiver: Lifen Chen; grant number: 82001367, receiver: Xi Liu), Natural Science Foundation of Chongqing (grant number: cstc2021jcyj-msxmX0180, receiver: Xi Liu), and Kuanren Talent Program of The Second Affiliated Hospital of Chongqing Medical University (receiver: Xi Liu)."