GDF15 alleviates the progression of benign tracheobronchial stenosis by inhibiting epithelial-mesenchymal transition and inactivating fibroblasts

作者全名："Liao, Jiaxin; Gan, Yiling; Peng, Mingyu; Giri, Mohan; Yang, Shu; Gu, Lei; Li, Anmao; Xiao, Rui; He, Chunyan; Li, Yishi; Bai, Yang; Xu, Li; Guo, Shuliang"

作者地址："[Liao, Jiaxin; Gan, Yiling; Peng, Mingyu; Giri, Mohan; Gu, Lei; Li, Anmao; Xiao, Rui; He, Chunyan; Li, Yishi; Bai, Yang; Xu, Li; Guo, Shuliang] Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China; [Yang, Shu] Chongqing Med Univ, Affiliated Hosp 1, Dept Psychiat, Chongqing 400016, Peoples R China"

通信作者："Xu, L; Guo, SL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, Chongqing 400016, Peoples R China."

来源：EXPERIMENTAL CELL RESEARCH

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000889664200001

JCR分区：Q2

影响因子：3.7

年份：2022

卷号：421

期号：2

开始页：　

结束页：　

文献类型：Article

关键词：Cytokine; GDF15; Peptide drugs; Organ damage and repair; Tracheobronchial stenosis; TGF-?1; Smad2; 3 signaling pathways

摘要："Benign tracheobronchial stenosis (BTS) is a fatal and incurable disease. Epithelial repair and matrix recon-struction play an important role in the wound repair process. If the interstitial context is not restored and sta-bilized in time, it can lead to pathological fibrosis. Here we attempted to identify cytokines that are involved in promoting wound repair. Growth differentiation factor 15 (GDF15) is a cytokine secreted by tracheal epithelial cells, which is indispensable for the growth of epithelial cells and inhibits the overgrowth of fibroblasts. GDF15 can counteract transforming growth factor-beta (TGF beta 1) stimulation of epithelial-mesenchymal transition (EMT) in tracheal epithelial cells and inhibit fibroblast activation via the TGF beta 1-SMAD2/3 pathway. In a rat model of tracheal stenosis, GDF15 supplementation alleviated the degree of tracheal stenosis. These results suggest that GDF15 prevents fibroblast hyperactivation and promotes epithelial repair in injured trachea. GDF15 may be a potential therapy to improve benign tracheobronchial stenosis."

基金机构：National Major Science and Tech-nology Projects of China; [2018ZX10302302003]

基金资助正文：Acknowledgements and Funding This work was supported by the National Major Science and Tech-nology Projects of China (grant no. 2018ZX10302302003) .