Salvage treatments for locally recurrent nasopharyngeal cancer: A systematic review and meta-analysis

作者全名："Wang, Dong; Liao, Mange; Wu, Jian; Luo, Wenlong; Qi, Siguo; Liu, Bo; Li, Jiarong"

作者地址："[Wang, Dong; Liao, Mange; Wu, Jian; Qi, Siguo; Liu, Bo; Li, Jiarong] Cent Hosp Dazhou, Dept Otolaryngol Head & Neck Surg, Dazhou, Sichuan, Peoples R China; [Luo, Wenlong] Chongqing Med Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp 2, Chongqing, Peoples R China; [Luo, Wenlong] Chongqing Med Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China"

通信作者："Luo, WL (通讯作者)，Chongqing Med Univ, Dept Otolaryngol Head & Neck Surg, Affiliated Hosp 2, 74 Linjiang Rd, Chongqing 400010, Peoples R China."

来源：HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000889962400001

JCR分区：Q1

影响因子：2.9

年份：2022

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文献类型：Review; Early Access

关键词：endoscopic surgery; outcome; recurrent nasopharyngeal carcinoma; re-irradiation; salvage treatment

摘要："The present study aimed to evaluate the effectiveness and safety of various salvage treatments to treat locally recurrent nasopharyngeal carcinoma (IrNPC). A comprehensive search was conducted to gather relevant research publications on salvage treatment for IrNPC. Specifically, 2-, 3-, and 5-year overall survival were the primary outcome. A total of 89 studies with 101 cohorts were collected. Endoscopic nasopharyngectomy was found to be associated with a significantly improved 5-year OS compared with CRT (p = 0.027) and IMRT (p = 0.016). Moreover, based on recurrence T classification, the 2-, 3-, and 5-year OS were similar across different treatments. Endoscopic nasopharyngectomy was associated with a significant reduction in treatment-related complications (grade >= 3) compared with IMRT (p < 0.001) and open nasopharyngectomy (p = 0.028). Endoscopic nasopharyngectomy may provide comparable treatment outcomes to re-irradiation, while offering a better safety profile for selective patients with resectable IrNPC."

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