"Exploring the psychological profile: a cross-sectional study of 1,185 patients with pulmonary nodules in an outpatient clinic"

作者全名："Zhuang, Weitao; Wu, Junhan; Xu, Haijie; Deng, Cheng; Li, Shaopeng; Tian, Dan; Ben, Xiaosong; Xu, Wei; Tang, Yong; Qiao, Guibin"

作者地址："[Zhuang, Weitao; Wu, Junhan; Deng, Cheng; Tian, Dan; Ben, Xiaosong; Tang, Yong; Qiao, Guibin] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Thorac Surg, 106 Zhongshan Second Rd, Guangzhou 510080, Peoples R China; [Wu, Junhan; Xu, Haijie; Qiao, Guibin] Shantou Univ, Med Coll, Shantou, Peoples R China; [Xu, Haijie] Shantou Univ, Affiliated Hosp 1, Med Coll, Dept Thorac Surg, Shantou, Peoples R China; [Li, Shaopeng] Longgang Cent Hosp Shenzhen, Dept Cardiothorac Surg, Shenzhen, Peoples R China; [Li, Shaopeng] Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China; [Xu, Wei] Chongqing Med Univ, Sch Publ Hlth & Management, Chongqing, Peoples R China"

通信作者："Tang, Y; Qiao, GB (通讯作者)，Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Thorac Surg, 106 Zhongshan Second Rd, Guangzhou 510080, Peoples R China."

来源：JOURNAL OF THORACIC DISEASE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000890302000001

JCR分区：Q3

影响因子：2.5

年份：2022

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Anxiety; depression; pulmonary nodules (PNs); treatment preference

摘要："Background: The purpose of this study was to identify the potential risk and protective factors of psychological burden in patients with pulmonary nodules (PNs) and to explore how the psychological status of the patients affects their treatment preferences.Methods: In this questionnaire-based study, 1,185 outpatients were evaluated using the Hospital Anxiety and Depression Scale (HADS), and the correlations between psychological burden and patients' sociodemographic and clinical characteristics were assessed. Results: Prevalence of anxiety and depression was 42.1% and 27.0%, respectively, among patients with PNs. Binary logistic regression analysis revealed that age over 60 years old [odds ratio (OR) =0.57; 95% confidence interval (CI): 0.36-0.89], computed tomography (CT) scan due to physical discomfort (OR =1.58; 95% CI: 1.11-2.24), multiple PNs (OR =1.52; 95% CI: 1.20-1.94), family history of malignancy (OR =1.28; 95% CI: 1.01-1.64), and subjective symptoms (OR =1.70; 95% CI: 1.32-2.19) were independently associated with anxiety, while multiple PNs (OR =1.51; 95% CI: 1.15-1.98), subjective symptoms (OR =1.65; 95% CI: 1.23-2.20), and indeterminate nodules (OR =1.91; 95% CI: 1.08-3.40) were independently associated with depression. There was a tendency for patients with anxiety and depression to choose more aggressive management strategies (P<0.001 and P=0.001, respectively). Univariate analysis showed that symptomatic patients (chi 2=9.696; P=0.021) and those with progressive nodules (chi 2=18.198, P=0.033) chose more aggressive treatment strategies.Conclusions: Anxiety and depression are common in patients with PNs, which might result in nonnegligible overtreatment. Presence of subjective symptoms can significantly exacerbate psychological burden and influence treatment preference. Taking psychological factors into consideration in the outpatient clinic may facilitate patient-centered communication and promote judicious decision-making."

基金机构："2020 Guangdong Provincial Special Project for Popularization of Science and Technology Innovation [2020A1414070007]; Natural Science Foundation of Guangdong Province [2022A1515012469]; Science and Technology Program of Guangzhou, China [202206010103]"

基金资助正文："This work was supported by the 2020 Guangdong Provincial Special Project for Popularization of Science and Technology Innovation (Grant No. 2020A1414070007); the Natural Science Foundation of Guangdong Province (Grant No. 2022A1515012469); and the Science and Technology Program of Guangzhou, China (Grant No. 202206010103)."