Multisite Captured Copper Ions via Phosphorus Dendrons Functionalized Electrospun Short Nanofibrous Sponges for Bone Regeneration

作者全名："Zhang, Jun; Chen, Liang; Wang, Juan; Lei, Yiting; Huang, Yanran; Xu, Jingtao; Hu, Ning; Huang, Wei; Cui, Wenguo; Luo, Xiaoji"

作者地址："[Zhang, Jun; Lei, Yiting; Huang, Yanran; Xu, Jingtao; Hu, Ning; Huang, Wei; Luo, Xiaoji] Chongqing Med Univ, Orthoped Lab, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China; [Chen, Liang; Wang, Juan; Cui, Wenguo] Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Sch Med,Dept Orthopaed, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China"

通信作者："Huang, W; Luo, XJ (通讯作者)，Chongqing Med Univ, Orthoped Lab, Affiliated Hosp 1, Dept Orthoped, Chongqing 400016, Peoples R China.; Cui, WG (通讯作者)，Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Sch Med,Dept Orthopaed, 197 Ruijin 2nd Rd, Shanghai 200025, Peoples R China."

来源：ADVANCED FUNCTIONAL MATERIALS

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000891054100001

JCR分区：Q1

影响因子：18.5

年份：2023

卷号：33

期号：5

开始页：　

结束页：　

文献类型：Article

关键词：3D short nanofibrous sponges; bone regeneration; copper ions; multisite capturing; phosphorus dendrons

摘要："Metal ions play an important role in promoting tissue regeneration. However, excessive metal ions can also cause certain damage to the human body. In this study, the electrospun short nanofibrous sponges (3D-NS) functionalized with phosphorus dendrons (3D-NS@PD) are innovatively constructed, which are capable of dynamically capturing free copper ions at multiple sites to realize the dynamic balance and physiological concentration of copper ions. First, phosphorus dendrons with the long hydrophobic alkyl chain are synthesized by substitution and condensation reactions with hexachlorocyclic triphosphazene as the core. Then, ten pyrrole groups are modified on the surface of phosphorus dendrons, some of which are grafted with copper ions by coordination method, and the remaining pyrrole groups are used to capture free copper ions at multiple sites. Furthermore, phosphorus dendrons modified with pyrrole groups are grafted onto 3D-NS via pi-pi conjugation. The captured copper ions can enhance the mechanical properties of the 3D-NS@PD, which shows stable 3D shape and reversible water absorption after repeated compression by external forces. In vitro and in vivo results show that 3D-NS@PD effectively promotes bone regeneration by accelerating the formation of neovascularization at the defect sites and regulating the osteogenic differentiation of local bone marrow mesenchymal stem cells."

基金机构："National Key Research and Development Program of China [2020YFA0908200]; National Natural Science Foundation of China [8187090823, 51873107, 32000937]; Shanghai Municipal Health Commission [20214Y0133]; Program of Shanghai Academic Research Leader [22XD1422600]; China Postdoctoral Science Foundation [2022M712130]; Innovative Project for doctoral students of the First Affiliated Hospital of Chongqing Medical University [CYYY-BSYJSCXXM-202215]"

基金资助正文："J.Z., L.C., and J.W. contributed equally to this work. This work was funded by the National Key Research and Development Program of China (2020YFA0908200), National Natural Science Foundation of China (8187090823, 51873107 and 32000937), Shanghai Municipal Health Commission (20214Y0133), Program of Shanghai Academic Research Leader (22XD1422600), China Postdoctoral Science Foundation (2022M712130) and the Innovative Project for doctoral students of the First Affiliated Hospital of Chongqing Medical University (CYYY-BSYJSCXXM-202215)."