Thyroid hormones regulate reelin expression in neuropsychiatric disorders

作者全名："Su, Yadi; Yang, Xiaoyu; Yang, Lu; Liu, Xinjing; She, Zhenghang; Zhang, Youwen; Dong, Zhifang"

作者地址："[Su, Yadi; Yang, Lu] Chongqing Med Univ, Coll Stomatol, Chongqing 401334, Peoples R China; [Yang, Xiaoyu; She, Zhenghang; Zhang, Youwen] Chongqing Med Univ, Coll Pediat, Chongqing 401334, Peoples R China; [Liu, Xinjing] Chongqing Med Univ, Coll Publ Hlth & Management, Chongqing 401334, Peoples R China; [Dong, Zhifang] Chongqing Med Univ, Pediat Res Inst,Chongqing Key Lab Translat Med Res, Natl Clin Res Ctr Child Hlth & Disorders,Key Lab C, Minist Educ,China Int Sci & Technol Cooperat Base, Chongqing 400014, Peoples R China"

通信作者："Dong, ZF (通讯作者)，Chongqing Med Univ, Pediat Res Inst,Chongqing Key Lab Translat Med Res, Natl Clin Res Ctr Child Hlth & Disorders,Key Lab C, Minist Educ,China Int Sci & Technol Cooperat Base, Chongqing 400014, Peoples R China."

来源：CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000891634300001

JCR分区：Q3

影响因子：1.7

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Review; Early Access

关键词：thyroid hormones; reelin; neurological diseases; pregnancy

摘要："The incidence and prevalence of hypothyroidism in pregnancy have increased over the past two decades, leading to the occurrence of neuropsychiatric disorders. However, the underlying mechanisms of thyroid hormone (TH)-regulated gene expression and neuropsychiatric development during the postnatal period remain unknown. Recent achievements have shown that reelin, a large extracellular glycoprotein, plays a crucial role in neuronal migration and localization during the development of neocortex and cerebellar cortex, thereby participating in the development of neuropsychiatric diseases. Reelin-induced neuronal migration requires triiodothyronine (T3) from the deiodination of thyroxine (T4) by fetal brain deiodinases. Previous studies have reported decreased reelin levels and abnormal gene expression, which are the same as the pathological alternations in reelin-induced neuropsychiatric disorders including schizophrenia and autism. Low T3 in the fetal brain due to hypothyroxinemia during pregnancy may be detrimental to neuronal migration, leading to neuropsychiatric disorders. In this review, we focus on the reelin expression between hypothyroidism and neuropsychiatric disorders."

基金机构："National Natural Science Foundation of China; Natural Science Foundation of Chongqing [82071395]; CQMU Program for Youth Innovation in Future Medicine [cstc2021ycjh-bgzxm018, cstc2020jcyj-zdxmX0004]; [W0044]"

基金资助正文："This work was supported by grants from the National Natural Science Foundation of China (Grant No. 82071395), the Natural Science Foundation of Chongqing (Grant No. cstc2021ycjh-bgzxm018 and cstc2020jcyj-zdxmX0004), and CQMU Program for Youth Innovation in Future Medicine (Grant No. W0044)."