A novel prognostic model based on three clinic-related miRNAs for prostate cancer

作者全名："Che, Ping; Jiang, Shihao; Zhang, Weiyang; Zhu, Huixuan; Hu, Daorong; Wang, Delin"

作者地址："[Che, Ping; Jiang, Shihao; Zhang, Weiyang; Zhu, Huixuan; Wang, Delin] Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China; [Che, Ping] Matern & Child Hlth Hosp Chongqing Hechuan, Dept Pediat Surg, Chongqing, Peoples R China; [Hu, Daorong] Peoples Hosp Hechuan, Dept Urol, Chongqing, Peoples R China"

通信作者："Wang, DL (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Urol, Chongqing, Peoples R China.; Hu, DR (通讯作者)，Peoples Hosp Hechuan, Dept Urol, Chongqing, Peoples R China."

来源：FRONTIERS IN SURGERY

ESI学科分类：　

WOS号：WOS:000891704100001

JCR分区：Q3

影响因子：1.8

年份：2022

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：PCA; miRNA; risk model; prognosis; bioinformactics

摘要："Background: Prostate cancer (PCa) is the second most common malignant tumor in men worldwide. MiRNAs have been reported to play significant roles in prognosis prediction for patients with malignant tumors. Methods: The survival-related miRNAs (sDMIRs) were identified by Cox regression analysis. A risk score model (RSM) was established based on three sDMIRs. The expression levels of sDMIRs in cell lines and clinical samples were detected via quantitative polymerase chain reaction. The correlations between sDMIRs and clinicopathological characteristics of PCa patients were evaluated using the chi-square test and Fisher's exact probability method. Results: Four sDMIRs were remarkably related to the prognosis of PCa patients based on univariate Cox analysis, of which miR-10a-5p, miR-20a-5p, and miR-508-3p were used to establish the RSM. The OS in the low-risk group was better than that in the high-risk group. In the verification of various prostate cell lines and clinical samples from 162 PCa patients, the prominently higher expression of miR-10a-5p and miR-20a-5p and lower expression of miR-508-3p were detected in PCa cell lines and tumor tissues, especially the more advanced T-stage. Besides, the higher expression of miR-20a-5p and miR-10a-5p was significantly correlated to the higher level of PSA, Gleason score, more advanced T-stage, and distant metastasis status. Conclusion: We identify and validate the clinical significance of three sDMIRs and establish a verified RSM to evaluate the prognosis for PCa patients. The findings not only provide a reliable tool for clinical decision-makers to evaluate patients' prognosis but also offer a novel perspective into the field of biomarker identification."

基金机构：program of Chongqing Science and Technology Bureau; [cstc2015jcyjBX0045]

基金资助正文：Funding The study was funded by the program of Chongqing Science and Technology Bureau (cstc2015jcyjBX0045).