Photo-sonodynamic therapy mediated with OLI_NPs to induce HPV16E7-specific immune response and inhibit cervical cancer in a murine model

作者全名："Zhao, Guangzong; Chen, Shuning; Zheng, Jiao; Li, Chenyang; Zhong, Xiaowen; Cao, Yang; Zheng, Yue; Sun, Jiangchuan; Zhu, Shenyin; Chang, Shufang"

作者地址："[Zhao, Guangzong; Chen, Shuning; Zheng, Jiao; Li, Chenyang; Zhong, Xiaowen; Zheng, Yue; Sun, Jiangchuan; Chang, Shufang] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, Chongqing 400010, Peoples R China; [Zhao, Guangzong] Chongqing Med Univ, Coll Biomed Engn, State Key Lab Ultrasound Med & Engn, Chongqing 400016, Peoples R China; [Zhao, Guangzong; Cao, Yang] Chongqing Med Univ, Affiliated Hosp 2, Inst Ultrasound Imaging, Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Zhu, Shenyin] Chongqing Med Univ, Affiliated Hosp 1, Dept Pharm, Chongqing 400016, Peoples R China; [Sun, Jiangchuan; Zhu, Shenyin; Chang, Shufang] Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, 74 Linjian Rd, Chongqing 400010, Peoples R China"

通信作者："Sun, JC; Zhu, SY; Chang, SF (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Obstet & Gynecol, 74 Linjian Rd, Chongqing 400010, Peoples R China."

来源：JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000891791300001

JCR分区：Q1

影响因子：3.9

年份：2023

卷号：238

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Cervical cancer; Photo-sonodynamic therapy; Multifunctional nanoparticles; Immunogenic cell death; Lipopolysaccharides

摘要："Cervical carcinoma is the fourth most common gynecological cancer. Here we reported the synthesis of oxygen -carried and lipopolysaccharide (LPS)/ indocyanine green (ICG)-loaded nanoparticles (OLI_NPs) for photo-sonodynamic therapy (PSDT) mediated combination therapy to induce systemic antitumor immune responses. We effectively built a new nanoparticle system, a multifunctional nanoagent that integrated the ability of dual -model imaging and therapy for tumors. In this study, we confirmed that OLI_NPs can act as a multifunctional platform that enables not only to diagnose tumors conveniently but also to efficiently provide treatment of in situ tumors, permitting simultaneous dual-mode imaging and localization of the therapy in combination with PSDT-mediated drug release. Furthermore, our combined strategy could effectively depress the tumor development and extend mouse life by the combination of inducing immunogenic cell death (ICD) with encapsulated LPS. In conclusion, combining therapy of OLI_NPs plus PSDT can induce anti-tumor immune responses and tumor antigen-specific immunity in a common TC-1 graft tumor model. Therefore, this combination therapy is a viable technique for cervical cancer treatment."

基金机构："National Natural Science Foundation of China [2022ZDXM007]; Natural Science Foundation Project of CQ CSTC, China [cstc2018jcyjAX0103]; Chongqing Medical Scientific Research Project [81972439]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University"

基金资助正文："Firstly, we want to express our gratitude to Dr. Tinghe Yu (Director of the Key Medical Laboratory of Obstetrics and Gynecology, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China) for providing the essential experimental infrastructure. Secondly, we are equally grateful to Dr. Yang Cao (Institute of Ultrasound Imaging, The Second Hospital of Chongqing Medical University, Chongqing, China) and Dr. Zhibiao Wang (Director of National Key Laboratory of Ultrasonic Engineering, Chongqing Medical University, Chongqing, China) for allowing us to accomplish the present study. Dr. Ting -Li Han (Department of Obstetrics and Gynecology, The Second Hospital of Chongqing Medical University, Chongqing, China) for language revision. Finally, I want to give a special thank you to my mentor for her valuable advice and continuous encouragement. This research was sponsored by the National Natural Science Foundation of China (81972439) , Natural Science Foundation Project of CQ CSTC, China (cstc2018jcyjAX0103) , Chongqing Medical Scientific Research Project (2022ZDXM007) and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University."