Association of decreases in PM2.5 levels due to the implementation of environmental protection policies with the incidence of obesity in adolescents: A prospective cohort study

作者全名："Liang, Xiaohua; Liu, Fangchao; Liang, Fengchao; Ren, Yanling; Tang, Xian; Luo, Shunqing; Huang, Daochao; Feng, Wei"

作者地址："[Liang, Xiaohua; Ren, Yanling; Tang, Xian; Luo, Shunqing; Huang, Daochao; Feng, Wei] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Dept Clin Epidemiol & Biostat, Minist Educ,Key Lab Child Dev & Disorders,Children, Chongqing 400016, Peoples R China; [Liu, Fangchao; Luo, Shunqing] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Epidemiol, Beijing 100037, Peoples R China; [Liang, Fengchao; Luo, Shunqing] Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen 518055, Peoples R China; [Liang, Xiaohua] 136 2nd St, Chongqing, Peoples R China"

通信作者："Liang, XH (通讯作者)，136 2nd St, Chongqing, Peoples R China."

来源：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

ESI学科分类：ENVIRONMENT/ECOLOGY

WOS号：WOS:000891793300005

JCR分区：Q1

影响因子：6.8

年份：2022

卷号：247

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Environmental protection policy; PM2; 5; Obesity; Obesity indicators; Children and adolescents

摘要："Aims: To explore the association between decreased levels of particulate matter (<= 2.5 mu m; PM2.5) due to the implementation of environmental protection policies and the incidence of obesity in adolescents in Chongqing, China through a prospective cohort study.Methods: A total of 2105 children (52.02% male; aged 7.33 +/- 0.60 years at baseline) were enrolled from the Chongqing Children's Health Cohort. A mixed linear regression model was used to analyse the relationships of PM2.5 levels with obesity indicators after adjusting for covariates. Additionally, a Poisson regression model was used to determine the relationship between PM2.5 exposure and the incidence of overweight/obesity.Results: The average PM2.5 exposure levels from participant conception to 2014, from 2015 to 2017, and from 2018 to 2019 were 66.64 +/- 5.33 mu g/m3, 55.49 +/- 3.78 mu g/m3, and 42.50 +/- 1.87 mu g/m3, respectively; these levels significantly decreased over time (P < 0.001). Throughout the entire follow-up period, the incidence of over-weight/obesity after a >= 25 mu g/m3 decrease in the PM2.5 level was 4.57% among females; this incidence was the lowest among females who experienced remarkable decreases in PM2.5 exposure. A 1-mu g/m3 decrease in the PM2.5 level significantly decreased the body mass index (BMI), BMI z score (BMIz), and weight of adolescents (all P < 0.001). Compared with a < 20-mu g/m3 decrease in the PM2.5 level, a >= 25-mu g/m3 decrease protected against increased BMI (net difference=-0.93; 95% confidence interval [CI]: (-1.23,-0.63) kg/m2), BMIz (-0.28 (-0.39,-0.17)), weight (-1.59 (-2.44,-0.74) kg), and incidence of overweight/obesity (0.48 (0.37, 0.62), P < 0.001). Moreover, compared with a < 20-mu g/m3 decrease in the PM2.5 level, a >= 25-mu g/m3 decrease resulted in significant absolute differences in BMI (-1.26 (-1.56,-0.96) kg/m2), BMIz (-0.53 (-0.65,-0.40)) and weight (-3.01 (-3.8,-2.19) kg) (all P < 0.001).Conclusions: This study showed the etiological relevance of declining PM2.5 concentrations for the incidence of obesity in children and adolescents, suggesting that controlling ambient air pollutants may prevent the devel-opment of obesity in this age group. Continuous implementation of environmental protection policies in China has led to substantial health benefits."

基金机构：Chongqing Science and Technology Bureau [CSTC2021jscx-gksb-N0001]; Research and Innovation Team of Chongqing Medical University [W0088]; Young and Middle-aged Medical Outstanding Expert Project of Chongqing Municipal Health Commission [78]; National Key Research and Development Project [2017YFC0211705]; Intelligent Medicine Project [ZHYX202109]; Technology Foresight and Institutional Innovation Project of Chongqing Science and Technology Bureau [cstc2020jsyj-zzysbAX0016]; Natural Science Foundation of Youth Project [81502826]; Education Commission of Chongqing Municipality [KJQN201900443]; Joint Medical Research Project of Chongqing Municipal Health Commission and Chongqing Science and Technology Bureau [2020MSXM062]

基金资助正文："This work was supported by the Chongqing Science and Technology Bureau (No. CSTC2021jscx-gksb-N0001), Research and Innovation Team of Chongqing Medical University (No. W0088), Young and Middle-aged Medical Outstanding Expert Project of Chongqing Municipal Health Commission (No. 78), National Key Research and Development Project (No. 2017YFC0211705), Intelligent Medicine Project (No. ZHYX202109), Joint Medical Research Project of Chongqing Municipal Health Commission and Chongqing Science and Technology Bureau (No. 2020MSXM062), Technology Foresight and Institutional Innovation Project of Chongqing Science and Technology Bureau (No. cstc2020jsyj-zzysbAX0016), Natural Science Foundation of Youth Project (No. 81502826) and Education Commission of Chongqing Municipality (No. KJQN201900443). The funders had no role in the study design, the data collection and analysis, the decision to publish, or the preparation of the manuscript."