Surface modification of titanium implant for repairing/improving microenvironment of bone injury and promoting osseointegration

作者全名："Ding, Yao; Tao, Bailong; Ma, Ruichen; Zhao, Xin; Liu, Peng; Cai, Kaiyong"

作者地址："[Ding, Yao; Ma, Ruichen; Liu, Peng; Cai, Kaiyong] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China; [Tao, Bailong] Chongqing Med Univ, Affiliated Hosp 1, Lab Res Ctr, Chongqing 400016, Peoples R China; [Zhao, Xin] Hong Kong Polytech Univ, Dept Biomed Engn, Kowloon, Hong Kong, Peoples R China"

通信作者："Liu, P; Cai, KY (通讯作者)，Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China."

来源：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000892642300001

JCR分区：Q1

影响因子：11.2

年份：2023

卷号：143

期号：　

开始页：1

结束页：11

文献类型：Article

关键词：Ti and its alloys; Osseointegration; Microenviroment; Nanoenzyme; Sr

摘要："Bone injury and implantation operation are often accompanied by microenvironment damage of bone tis-sue, which seriously affects the process of osseointegration of implants, especially for titanium (Ti)-based bioinert materials. Thus, repairing or improving the microenvironment of damaged bone tissue is of great significance for bone rescue, reconstruction, and regeneration, which is still a major medical challenge. Oxidative stress (OS) and oxygen (O2) deficiency are considered to be specific physiological signals of the bone-injury microenvironment. From the above background, a coating consisting of manganese dioxide (MnO2) nanoenzyme and strontium (Sr) ions was fabricated on the surface of the Ti implant via a one -step hydrothermal treatment. MnO2 nanoenzyme presented in the coating alleviated OS and O2 deficiency at the injury site by catalyzing the decomposition of abundant endogenous H2O2 around the modified Ti implants into O2. In addition, Sr ions were released from the surface of the implant at a certain rate in a body-fluid environment, further promoting the adhesion, growth, and osteogenic differentiation of mesenchymal stem cells. More importantly, a Sprague Dawley rat femur model demonstrated that the modified Ti implant showed significant potential to accelerate bone tissue reconstruction in vivo. In sum-mary, the present system provides a new idea for the treatment of bone injury and the development of new orthopedic implants.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology."

基金机构："National Natural Science Foundation of China [32171327, 21734002, 51825302]; Natural Science Foundation of Chongqing [cstc2021jcyj-cxttX0002]"

基金资助正文："This work was financially supported by the National Natural Science Foundation of China (Nos. 32171327 , 21734002 , and 51825302) , and the Natural Science Foundation of Chongqing (No. cstc2021jcyj-cxttX0002) . The Analytical and Testing Center of Chongqing University is greatly acknowledged for its help with the characterization of materials."