Cartilage-targeting and inflammatory-responsive nanocarriers for effective osteoarthritis treatment via reactive oxygen species scavenging and anti-angiogenesis

作者全名："Wang, Sixiang; Gao, Yan; Dong, Lili; Chen, Peixing; Liu, Wanqian; Yang, Li"

作者地址："[Wang, Sixiang; Gao, Yan; Liu, Wanqian; Yang, Li] Chongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China; [Dong, Lili] Chongqing Med Univ, Dept Orthopaed, Affiliated Hosp 1, Chongqing 400042, Peoples R China; [Chen, Peixing] Chongqing Univ Sci & Technol, Sch Met & Mat Engn, Chongqing Key Lab Nano Micro Composite Mat & Devic, Chongqing 401331, Peoples R China"

通信作者："Liu, WQ; Yang, L (通讯作者)，Chongqing Univ, Coll Bioengn, Natl Innovat & Attracting Talents base 111, Key Lab Biorheol Sci & Technol Minist Educ, Chongqing 400030, Peoples R China."

来源：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000892642300004

JCR分区：Q1

影响因子：11.2

年份：2023

卷号：143

期号：　

开始页：30

结束页：42

文献类型：Article

关键词：Osteoarthritis; Reactive oxygen species; Angiogenesis; Cartilage-targeting; Drug delivery systems; Chitosan-catechol nanocarriers

摘要："Osteoarthritis (OA), a common disabling joint disease, is highly associated with microenvironmental changes in the cartilage and subchondral bone. Elevated reactive oxygen species (ROS) in the cartilage and subchondral bone angiogenesis accelerate articular cartilage erosion. New cartilage-targeting drug deliv-ery systems that are aimed at preventing ROS production and angiogenesis may be of clinical significance for OA treatment. Herein, an ROS scavenger and an inflammatory-responsive nanocarrier are designed by immobilizing the natural polyphenol (curcumin) in chitosan-catechol nanoformulations (Cur-CS-C NPs) via boronate ester. The robust cartilage-targeting effects and ROS scavenging capacities of Cur-CS-C NPs were respectively determined in cartilage explants and chondrocytes. Intra-articular injection of Cur-CS-C NPs in OA rat models efficiently suppressed angiogenesis and cartilage degradation partially via the ROS-mediated NF-Kappa B/PI3K-Akt signaling pathway. The developed curcumin-functionalized nanocarriers can significantly delay OA progression and provide a promising therapeutic strategy for other inflamma-tory diseases that are characterized by oxidative stress and angiogenesis.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology."

基金机构：National Natural Science Foundation of China; Innovation and Attracting Talents Program for College and Univer- sity; [11532004]; [11832008]; [B06023]

基金资助正文：This work was financially supported by the National Natural Science Foundation of China (Nos. 11532004 and 11832008) ; the Innovation and Attracting Talents Program for College and Univer- sity (?111? Project) (No. B06023) . We thank Home for Researchers editorial team ( www.home- for- researchers.com ) for the language editing service.