Effect of remote ischemic preconditioning in patients undergoing laparoscopic colorectal cancer surgery: a randomized controlled trial

作者全名："Yang, Xiuming; Tian, Chun; Gao, Yuansong; Yang, Liu; Wu, You; Zhang, Na"

作者地址："[Yang, Xiuming; Tian, Chun; Gao, Yuansong; Yang, Liu; Wu, You; Zhang, Na] Chongqing Med Univ, Yongchuan Hosp, Dept Anesthesiol & Perioperat Med, Chongqing 402160, Peoples R China"

通信作者："Tian, C (通讯作者)，Chongqing Med Univ, Yongchuan Hosp, Dept Anesthesiol & Perioperat Med, Chongqing 402160, Peoples R China."

来源：SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000893950400001

JCR分区：Q3

影响因子：1.6

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Remote ischemic preconditioning; laparoscopic colorectal cancer surgery; prolonged post-operative ileus; gastrointestinal tolerance; gut function

摘要："Background: Remote ischemic preconditioning (RIPC) is reported to reduce ischemia-reperfusion injury (IRI) in many vital organs by inhibiting a systemic inflammatory response. Inflammation also plays an essential role in the pathophysiology of prolonged post-operative ileus (PPOI) in patients undergoing colorectal cancer (CRC) surgery. However, the role of RIPC is unclear in reducing the incidence of PPOI in patients undergoing CRC surgery. Methods: This was a prospective, randomized trial of RIPC vs. placebo-controlled in patients undergoing elective laparoscopic CRC surgery. Eighty patients were randomized to either a RIPC group or a control group (40 per arm), with computer-generated randomization. The aim was to determine whether RIPC improved the recovery of gut function. The primary outcomes assessed were time to gastrointestinal tolerance and incidence of PPOI. Results: Median time to stool of the RIPC group was significantly lower than that of the control group [RIPC vs. control, 4.0 (3.0, 6.0) vs. 5.0 (4.0, 7.8) days, p = 0.027]. Median time to gastrointestinal tolerance and incidence of PPOI in the RIPC group were lower than the control group; however, there were no statistical differences between the two groups [RIPC vs. control: 5.0 (3.0, 7.0) vs. 6.0 (4.0, 8.8) days, p = 0.178; 15 vs. 30%, p = 0.108]. Conclusion: RIPC could shorten the median time to stool in patients undergoing laparoscopic CRC surgery, but did not improve the overall recovery time of gut function or reduce the incidence of PPOI."

基金机构："Chongqing Municipal Science and Health Joint Medical Research Project of China; Natural Science Foundation of Yongchuan District, Chongqing, China; [2020FYYX033]; [2020nb0229]"

基金资助正文："This trial was funded by the Chongqing Municipal Science and Health Joint Medical Research Project of China (2020FYYX033) and the Natural Science Foundation of Yongchuan District, Chongqing, China (Ycstc, 2020nb0229)."