Phase-changeable nanoparticles loaded with FeIII-tannic acid/paclitaxel for retinoblastoma treatment

作者全名："Bin, Li; Du, Yangrui; Zhang, Yu; Xiao, Qibin; Chen, Xiaoli; Liu, Zhongshun; Du, Zhiyu"

作者地址："[Bin, Li; Du, Yangrui; Du, Zhiyu] Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Bin, Li; Chen, Xiaoli] Leshan Peoples Hosp, Dept Ophthalmol, Leshan 614000, Sichuan, Peoples R China; [Zhang, Yu] Chongqing Mingda Eye Hosp, Chongqing 400050, Peoples R China; [Xiao, Qibin] Chongqing Med Univ, Affiliated Hosp 2, State Key Lab Ultrasound Med & Engn, Chongqing 400010, Peoples R China; [Liu, Zhongshun] Leshan Aier Eye Hosp, Leshan 614000, Sichuan, Peoples R China"

通信作者："Du, ZY (通讯作者)，Chongqing Med Univ, Dept Ophthalmol, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000896894700005

JCR分区：Q1

影响因子：5

年份：2022

卷号：78

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Retinoblastoma; Nanoparticles; Targeted therapy

摘要："In this study, phase-changeable nanoparticles consisting of poly(lactic-co-glycolic acid) (PLGA) shells with FeIII- tannic acid (FeIIITA), paclitaxel (PTX), and perfluorinated pentane (PFP) were prepared, and their therapeutic effect on retinoblastoma (RB) was evaluated. The killing effect of the FeIIITA/PLGA/PTX/PFP (FPTP) + laser (FPTP + laser) treatment on Y79 cells was stronger than that of the blank control, laser, and FPTP treatments. Moreover, this effect increased with increasing concentration. In vivo experiments showed that the nanoparticles clustered at the tumor sites in mice and that laser excitation produced heat. The tumor volume increased gradually over time in the blank control and laser groups but not in the PTX, PLGA/PTX/PFP + laser, and FPTP groups. The FPTP + laser group showed the best tumor-volume-reduction results. The results collectively suggest that FPTP nanoparticles have good therapeutic effects on RB and may potentially be applied as a new integrated approach for RB diagnosis and treatment."

基金机构："Chongqing Natural Science Foundation, Chongqing Basic Research and Frontier Exploration Project [cstc2018jcy jA0809]"

基金资助正文："This work was supported by the Chongqing Natural Science Foundation, Chongqing Basic Research and Frontier Exploration Project [grant numbers: cstc2018jcy jA0809] . The funding agency had no role in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the article for publication."