"Comprehensive Assessment of ER alpha, PR, Ki67, P53 to Predict the Risk of Lymph Node Metastasis in Low-Risk Endometrial Cancer"

作者全名："Huang, Yuzhen; Jiang, Peng; Kong, Wei; Tu, Yuan; Li, Ning; Wang, Jinyu; Zhou, Qian; Yuan, Rui"

作者地址："[Huang, Yuzhen; Jiang, Peng; Kong, Wei; Tu, Yuan; Li, Ning; Wang, Jinyu; Zhou, Qian; Yuan, Rui] Chongqing Med Univ, Dept Gynecol, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Yuan, R (通讯作者)，Chongqing Med Univ, Dept Gynecol, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：JOURNAL OF INVESTIGATIVE SURGERY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000899046300001

JCR分区：Q2

影响因子：2.1

年份：2023

卷号：36

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Lymph node metastasis; endometrial cancer; prediction model; combined ratio; early stage

摘要："Purpose According to international guidelines, selective lymph node dissection can be performed on patients with early-stage endometrial cancer. However, some patients at early stage have already occurred lymph node metastasis at the time of diagnosis. This study was aimed to find a method to predict the risk of lymph node metastasis in this part of patient. Methods We collected data from 571 patients as training cohort and 351 patients as validation cohort for this study. Then we performed univariate and multivariate analyses to confirm the correlation of frequently used factors and lymph node metastasis. Combined analysis of four commonly indicators (ER alpha, PR, P53 and Ki67) from pathological parameter sources was mainly carried out, and the combined ratio is defined as (ER alpha + PR)/(Ki67 + P53). Then the accuracy of the combined ratio and other factors in prediction were compared by AUC value. Also, the optimal truncation value was searched. Finally, patients followed up for more than two years were divided into groups by the threshold value, and their difference in survival was explored. Results This study showed that CA125, grade, LVSI, ER alpha, PR, P53, Ki67 have statistical significance (P-value <0.05). The AUC value of combined ratio is 0.876, which is the best. The best cutoff value of combined ratio is 1.38 Conclusion The combined ratio cutoff value of 1.38 in this study can be used for prediction of risk of lymph node metastasis in early-stage endometrial cancer patients and provide a reference for therapeutic planning."

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