Role of angiotensin II in aging

作者全名："Yi, Wenmin; Chen, Fei; Zhang, Huiji; Tang, Peng; Yuan, Minghao; Wen, Jie; Wang, Shengyuan; Cai, Zhiyou"

作者地址："[Yi, Wenmin; Chen, Fei; Zhang, Huiji; Yuan, Minghao; Wang, Shengyuan; Cai, Zhiyou] Chongqing Med Univ, Dept Neurol, Chongqing, Peoples R China; [Yi, Wenmin; Chen, Fei; Zhang, Huiji; Tang, Peng; Yuan, Minghao; Wang, Shengyuan; Cai, Zhiyou] Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China; [Yi, Wenmin; Chen, Fei; Zhang, Huiji; Tang, Peng; Yuan, Minghao; Wang, Shengyuan; Cai, Zhiyou] Univ Chinese Acad Sci, Chongqing Sch, Chongqing, Peoples R China; [Yi, Wenmin; Chen, Fei; Zhang, Huiji; Yuan, Minghao; Wang, Shengyuan; Cai, Zhiyou] Chongqing Gen Hosp, Dept Neurol, Chongqing, Peoples R China; [Yi, Wenmin; Chen, Fei; Yuan, Minghao; Wen, Jie; Wang, Shengyuan; Cai, Zhiyou] Chongqing Key Lab Neurodegenerat Dis, Chongqing, Peoples R China; [Wen, Jie] Guangdong Med Univ, Dept & Inst Neurol, Zhanjiang, Guangdong, Peoples R China"

通信作者："Cai, ZY (通讯作者)，Chongqing Med Univ, Dept Neurol, Chongqing, Peoples R China.; Cai, ZY (通讯作者)，Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing, Peoples R China.; Cai, ZY (通讯作者)，Univ Chinese Acad Sci, Chongqing Sch, Chongqing, Peoples R China.; Cai, ZY (通讯作者)，Chongqing Gen Hosp, Dept Neurol, Chongqing, Peoples R China.; Cai, ZY (通讯作者)，Chongqing Key Lab Neurodegenerat Dis, Chongqing, Peoples R China."

来源：FRONTIERS IN AGING NEUROSCIENCE

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000899083000001

JCR分区：Q2

影响因子：4.8

年份：2022

卷号：14

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：aging; angiotensin II; reactive oxygen species; mitochondrial dysfunction; telomere attrition

摘要："Aging is an inevitable progressive decline in physiological organ function that increases the chance of disease and death. The renin-angiotensin system (RAS) is involved in the regulation of vasoconstriction, fluid homeostasis, cell growth, fibrosis, inflammation, and oxidative stress. In recent years, unprecedented advancement has been made in the RAS study, particularly with the observation that angiotensin II (Ang II), the central product of the RAS, plays a significant role in aging and chronic disease burden with aging. Binding to its receptors (Ang II type 1 receptor - AT(1)R in particular), Ang II acts as a mediator in the aging process by increasing free radical production and, consequently, mitochondrial dysfunction and telomere attrition. In this review, we examine the physiological function of the RAS and reactive oxygen species (ROS) sources in detail, highlighting how Ang II amplifies or drives mitochondrial dysfunction and telomere attrition underlying each hallmark of aging and contributes to the development of aging and age-linked diseases. Accordingly, the Ang II/AT(1)R pathway opens a new preventive and therapeutic direction for delaying aging and reducing the incidence of age-related diseases in the future."

基金机构：Construction Project of Capacity Improvement Plan for Chongqing Municipal Health Commission Affiliated Unit [(2019NLTS001)-ZS03174]; Operating Grant to Chongqing Key Laboratory of Neurodegenerative Diseases [1000013]; Plan for High-level Talent Introduction [2000055]

基金资助正文："This work was supported by the Construction Project of Capacity Improvement Plan for Chongqing Municipal Health Commission Affiliated Unit (2019NLTS001)-ZS03174, Operating Grant to Chongqing Key Laboratory of Neurodegenerative Diseases (1000013), and Plan for High-level Talent Introduction (2000055)."