Trends in the contributions of atopic family history to pediatric food sensitization and allergy

作者全名："Fang, Heping; Ma, Zhuoying; Chen, Lin; Xian, Ruoling; Wang, Juan; Chen, Jing; Li, Haiqi; Hu, Yan"

作者地址："[Fang, Heping; Ma, Zhuoying; Chen, Lin; Xian, Ruoling; Wang, Juan; Chen, Jing; Li, Haiqi; Hu, Yan] Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Minist Educ,Key Lab Child Dev & Disorders,Chongqin, Chongqing, Peoples R China"

通信作者："Hu, Y (通讯作者)，Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Childrens Hosp, Minist Educ,Key Lab Child Dev & Disorders,Chongqin, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000899432800001

JCR分区：Q2

影响因子：2.6

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：children; family history of atopic diseases (FHA); food allergy (FA); food sensitization (FS); trends

摘要："ObjectiveFamily history of atopic diseases (FHA) contributes to food allergy (FA). But little is known whether FHA primarily increases IgE-mediated, non-IgE-mediated FA, or both. And the trends in the contributions of FHA to food sensitization (FS) and FA remain unclear. We aim to clarify the associations among FHA, FS and FA and to understand the trends in the contributions of FHA to FS and FA. MethodsWe used chi-square test and mediating effect model to analyze the associations among FHA, FS and FA through comparisons between two cross-sectional investigations on FA in children under 2 years old in 2009 and 2019. ResultsIn 2009 and 2019, the positive FHA proportion tended to be increasing without significance (28.9% to 31.6%, P = 0.39). Subgroup analysis showed the FS rate in FA group decreased significantly (37/39 to 44/62, P = 0.003). In 2009, the FS rate and FA prevalence were higher in FHA (+) group than in FHA (-) group (26% vs. 14.7%, P = 0.008 and 15% vs. 7.7%, P = 0.03), and FS had a complete mediating effect on the association between FHA and FA (Z = 2.54, P = 0.011), but the results lost significance in 2019. ConclusionsThe association between FHA and FA was completely mediated by FS, which means FHA mainly increases IgE-mediated FA. And the contributions of FHA to FS and FA tended to be stabilized or even diminished, which means FHA alone could no longer be enough to screen high-risk children."

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