A paraventricular thalamus to central amygdala neural circuit modulates acute stress-induced heightened wakefulness

作者全名："Zhao, Juanjuan; Liu, Chengyu; Zhang, Fenyan; Zheng, Ziyi; Luo, Fenlan; Xia, Jianxia; Wang, Yaling; Zhang, Zehui; Tang, Jinxiang; Song, Zhenbo; Li, Siyu; Xu, Kan; Chen, Mengting; Jiang, Chenggang; He, Chao; Tang, Ling; Hu, Zhian; Gao, Dong; Ren, Shuancheng"

作者地址："[Zhao, Juanjuan; Liu, Chengyu; Chen, Mengting; Gao, Dong] Army Med Univ, Daping Hosp, Dept Sleep & Psychol, Chongqing 400042, Peoples R China; [Zhao, Juanjuan; Zhang, Fenyan; Tang, Ling] Chongqing Med Univ, Univ Town Hosp, Dept Neurol, Chongqing 401331, Peoples R China; [Zheng, Ziyi; Luo, Fenlan; Xia, Jianxia; Wang, Yaling; Song, Zhenbo; Li, Siyu; Xu, Kan; He, Chao; Hu, Zhian; Ren, Shuancheng] Army Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China; [Liu, Chengyu] Chongqing Med Univ, Dept Neurol, Affiliated Rehabil Hosp, Chongqing 400050, Peoples R China; [Zhang, Zehui] Jilin Univ, Coll Basic Med Sci, Dept Physiol, Changchun 130021, Peoples R China; [Tang, Jinxiang] Chongqing Med Univ, Sleep & Psychol Ctr, Bishan Hosp, Chongqing 402760, Peoples R China; [Jiang, Chenggang] Chongqing Med Univ, Chongqing Hlth Ctr Women & Children, Psychol Dept, Women & Childrens Hosp, Chongqing 401147, Peoples R China; [Hu, Zhian] Chongqing Inst Brain & Intelligence, Guangyang Bay Lab, Chongqing 400064, Peoples R China; [Ren, Shuancheng] Army Med Univ, Army Hosp 953, Shigatse 857000, Peoples R China"

通信作者："Gao, D (通讯作者)，Army Med Univ, Daping Hosp, Dept Sleep & Psychol, Chongqing 400042, Peoples R China.; Tang, L (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Dept Neurol, Chongqing 401331, Peoples R China.; Hu, Z; Ren, SC (通讯作者)，Army Med Univ, Coll Basic Med Sci, Dept Physiol, Chongqing 400038, Peoples R China.; Hu, Z (通讯作者)，Chongqing Inst Brain & Intelligence, Guangyang Bay Lab, Chongqing 400064, Peoples R China.; Ren, SC (通讯作者)，Army Med Univ, Army Hosp 953, Shigatse 857000, Peoples R China."

来源：CELL REPORTS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000900781800005

JCR分区：Q1

影响因子：8.8

年份：2022

卷号：41

期号：11

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Heightened wakefulness in response to stressors is essential for survival but can also lead to sleep disorders like insomnia. The paraventricular thalamus (PVT) is both a critical thalamic area for wakefulness and a stress -sensitive brain region. However, whether the PVT and its neural circuitries are involved in controlling wake-fulness in stress conditions remains unknown. Here, we find that PVT neurons projecting to the central amyg-dala (CeA) are activated by different stressors. These neurons are wakefulness-active and increase their ac-tivities upon sleep to wakefulness transitions. Optogenetic activation of the PVT-CeA circuit evokes transitions from sleep to wakefulness, whereas selectively silencing the activity of this circuit decreases time spent in wakefulness. Specifically, chemogenetic inhibition of CeA-projecting PVT neurons not only al-leviates stress responses but also attenuates the acute stress-induced increase of wakefulness. Thus, our results demonstrate that the PVT-CeA circuit controls physiological wakefulness and modulates acute stress-induced heightened wakefulness."

基金机构："National Major Project of China Science and Technology Innovation 2030 for Brain Science and Brain -Inspired Technology [2021ZD0203400, 2022ZD0205600]; National Natural Science Foundation of China [81971241, 31921003, 32000713, 31900727]"

基金资助正文："We thank all the members from Z.H.'s lab for critical comments on the manu- script. This work was supported by the National Major Project of China Science and Technology Innovation 2030 for Brain Science and Brain -Inspired Technology (2021ZD0203400 to Z.H. and 2022ZD0205600 to S.R.) and the National Natural Science Foundation of China (81971241 to D.G., 31921003 to Z.H., 32000713 to S.R., and 31900727 to Y.W.) ."