Low LH level does not indicate poor IVF cycle outcomes with GnRh-a single trigger: a retrospective analysis

作者全名："Li, Xue-Fei; Wang, Qiao-Feng; He, Qi-Qi; Wang, Xue-Jiao; Lv, Xing-Yu; Tang, Xiao-Jun; Zhong, Zhao-Hui; Ding, Yu-Bin; Wan, Qi"

作者地址："[Li, Xue-Fei; He, Qi-Qi; Wang, Xue-Jiao; Lv, Xing-Yu; Wan, Qi] Chengdu Jinjiang Hosp Womens & Childrens Hlth, Reprod Ctr, Chengdu 610041, Sichuan, Peoples R China; [Wang, Qiao-Feng; Tang, Xiao-Jun; Zhong, Zhao-Hui] Chongqing Med Univ, Sch Publ Hlth, Joint Int Res Lab Reprod & Dev, Minist Educ China, Chongqing 400016, Peoples R China; [Wang, Qiao-Feng; Tang, Xiao-Jun; Zhong, Zhao-Hui] Chongqing Med Univ, Sch Publ Hlth, Dept Epidemiol, Chongqing, Peoples R China; [Wang, Qiao-Feng; Ding, Yu-Bin] Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China"

通信作者："Wan, Q (通讯作者)，Chengdu Jinjiang Hosp Womens & Childrens Hlth, Reprod Ctr, Chengdu 610041, Sichuan, Peoples R China.; Ding, YB (通讯作者)，Chongqing Med Univ, Dept Obstet & Gynecol, Women & Childrens Hosp, Chongqing 401147, Peoples R China."

来源：BMC PREGNANCY AND CHILDBIRTH

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000901730300002

JCR分区：Q2

影响因子：3.1

年份：2022

卷号：22

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：IVF/ICSI; GnRH-a single trigger; LH levels; hCG retrigger

摘要："Objective: To compare the in vitro fertilization/intracytoplasmic sperm injection (IVF/ICSI) cycle outcomes between patients with low and normal serum luteinizing hormone (LH) levels on the day after a gonadotropin-releasing hormone agonist (GnRH-a) single trigger. We further investigated the efficacy of human chorionic gonadotropin (hCG) retrigger on IVF cycle outcomes in patients with low LH levels after GnRH-a single trigger. Methods: We retrospectively analyzed 957 infertile patients (tubal factor, ovulation disorders, male sperm factor, or unexplained infertility) who were treated with IVF/ICSI at the Chengdu Xinan Gynecology Hospital from July 2017 to December 2020. Patients received sufficient GnRH-a single trigger were divided into two groups based on the serum LH levels on the next day of trigger: normal serum LH levels (>= 10 mIU/mL) group (control group, n = 906) and low LH levels (< 10 mIU/mL) group (experimental group, n = 51). And the efficacy of hCG retrigger on IVF/ICSI cycle outcomes in 10 patients with low LH levels after GnRH-a single trigger. Results: There were no significant differences in IVF/ICSI cycle outcomes, including egg yield, two pronuclei fertilization rate, excellent embryo rate, or live birth rate of frozen-thawed embryos between patients with low and normal LH levels after GnRH-a trigger. It showed significantly higher risk of ovarian hyperstimulation syndrome in the group of low LH levels [ 0.7%(1/137) vs. 8.5%(4/47), P = 0.016] compared with the group of normal LH levels who received GnRH-a single trigger. The hCG retrigger had no obvious efficacy on cycle outcomes in patients with low LH levels, including oocytes retrieved, fertilization rate, embryo conditions, and live birth rate of frozen-thawed cycles. Conclusion: The IVF/ICSI cycle outcomes of patients with low LH levels on the day after GnRH-a administration were similar to those of patients with normal LH levels. Blood LH test might not be required on the day following the trigger. The hCG retrigger did not have any effect on the cycle outcomes, suggesting that immediate retriggering with hCG was unnecessary."

基金机构：Medical Science and Technology Project of Sichuan Provincial Health Committee; [21PJ166]

基金资助正文：This study was funded by the Medical Science and Technology Project of Sichuan Provincial Health Committee (21PJ166).