Baicalin regulates TLR4/IkBa/NFkB signaling pathway to alleviate inflammation in Doxorubicin related cardiotoxicity

作者全名："Feng, Panpan; Yang, Yue; Liu, Neng; Wang, Sihang"

作者地址："[Feng, Panpan; Liu, Neng] Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing, Peoples R China; [Yang, Yue] Chongqing Med Univ, Coll Sch Tradit Chinese Med, Chongqing 400016, Peoples R China; [Wang, Sihang] Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1 Youyi Rd, Chongqing 400042, Peoples R China"

通信作者："Wang, SH (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Radiol, 1 Youyi Rd, Chongqing 400042, Peoples R China."

来源：BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

ESI学科分类：BIOLOGY & BIOCHEMISTRY

WOS号：WOS:000904705300001

JCR分区：Q2

影响因子：3.1

年份：2022

卷号：637

期号：　

开始页：1

结束页：8

文献类型：Article

关键词：Baicalein; Doxorubicin; Cardiotoxicity; TLR4; Inflammatory

摘要："Cancers and the toxic and side effects of their treatment have always been a major problem for human beings. Doxorubicin (DOX) is one of the classical anthracycline antineoplastic drugs, but it can cause different degrees of heart damage and even serious heart failure. The incidence of myocardial toxicity increased significantly when the cumulative dose of the drug was more than 550 mg/m2, and the relevant mechanism was related to the inflammatory reaction, reactive oxygen species and the apoptosis of cardiomyocytes in the myocardium. Relevant studies have shown that baicalein (Ba) can inhibit NFkB-related inflammatory signaling pathway protects cardiac function, but whether it can inhibit DOX induced cardiotoxicity has not been reported. Therefore, in animal studies, we explored the effects of doxorubicin and baicalein on cardiac function, TLR4/IkBa/NFkB signaling pathway and related inflam-matory indicators in rats. In cell experiments, by silencing or overexpressing TLR4, we explored whether baicalein could achieve anti-inflammatory effect through regulating TLR4/IkBa/NFkB signaling pathway and ultimately inhibit doxorubicin induced cardiotoxicity. (c) 2022 Published by Elsevier Inc."

基金机构：Chongqing Municipal Health and Health Committee; [ZQNYXGDRCGZS2019001]; [2019ZY3340]

基金资助正文："Funding This work was supported by the Chongqing Municipal Health and Health Committee (ZQNYXGDRCGZS2019001, No. 2019ZY3340)"