Impact of the De Ritis Ratio on the Prognosis of Patients with Stable Coronary Artery Disease Undergoing Percutaneous Coronary Intervention

作者全名："Wang, Kai; Chen, Zijun; Zeng, Deli; Ran, Maojuan"

作者地址："[Wang, Kai; Chen, Zijun; Zeng, Deli; Ran, Maojuan] Chongqing Med Univ, Dept Cardiol, Yongchuan Hosp, Chongqing, Peoples R China"

通信作者："Ran, MJ (通讯作者)，Chongqing Med Univ, Dept Cardiol, Yongchuan Hosp, Chongqing, Peoples R China."

来源：MEDICAL SCIENCE MONITOR

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000904741200001

JCR分区：Q3

影响因子：3.1

年份：2022

卷号：28

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Alanine Transaminase; Aspartate Aminotransferases; Coronary Artery Disease; Prognosis

摘要："Background: The aim of this study was to emphasize the impact of the aspartate aminotransferase-to-alanine aminotrans- ferase ratio (De Ritis ratio) on the prognosis of patients with stable coronary artery disease (SCAD) undergo- ing percutaneous coronary intervention (PCI).Material/Methods: Patients with SCAD who underwent elective PCI at Shinonoi General Hospital were included. SCAD was defined as epicardial coronary artery diameter stenosis >= 90% or epicardial coronary artery diameter stenosis >= 75% ac- companied by symptoms or stress-induced myocardial ischemia. Clinical data were collected, and cardiovascu- lar events were followed after discharge. One-way Cox proportional risk analysis was performed to assess the risk stratification value of the De Ritis ratio, using major adverse cardiac and cerebrovascular events (MACCE) and all-cause mortality as the primary and secondary endpoints, respectively. The independent risk stratifica- tion value was evaluated by multivariate Cox proportional risk analysis.Results: Among 204 patients with SCAD undergoing PCI, during a median follow-up period of 706 days (24 months), 13.7% (28/204) patients experienced MACCE, and 8.8% (18/204) experienced all-cause mortality. Multifactorial Cox regression analysis revealed that a high De Ritis ratio was an independent risk factor for MACCE (HR=2.96, 95% CI: 1.29-6.78, P=0.01) and all-cause mortality (HR=3.61, 95% Cl: 1.31-9.86, P=0.012). The sensitivity anal- ysis further confirmed the incremental value of the De Ritis ratio for adverse cardiovascular events.Conclusions: A high De Ritis ratio was an independent and valuable risk stratification factor for MACCE and all-cause mor- tality in patients with SCAD after PCI."

基金机构：　

基金资助正文：