Decreased antibody response to influenza vaccine with an enhanced antibody response to subsequent SARS-CoV-2 vaccination in patients with chronic hepatitis B virus infection

作者全名："He, Taiyu; Ling, Ning; Zhang, Gaoli; Xiang, Dejuan; Hu, Peng; Peng, Mingli; Cai, Dachuan; Zhang, Dazhi; Chen, Min; Ren, Hong"

作者地址："[He, Taiyu; Ling, Ning; Zhang, Gaoli; Xiang, Dejuan; Hu, Peng; Peng, Mingli; Cai, Dachuan; Zhang, Dazhi; Chen, Min; Ren, Hong] Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis,Minist Educ,Dept Infec, 288 Tianwen Ave, Chongqing 401336, Peoples R China"

通信作者："Chen, M; Ren, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Inst Viral Hepatitis, Key Lab Mol Biol Infect Dis,Minist Educ,Dept Infec, 288 Tianwen Ave, Chongqing 401336, Peoples R China."

来源：IMMUNITY INFLAMMATION AND DISEASE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000905237100001

JCR分区：Q3

影响因子：3.1

年份：2023

卷号：11

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：CHB; cirrhosis; influenza; SARS-CoV-2; immune response

摘要："IntroductionInfluenza or SARS-CoV-2 vaccination is especially recommended for people with underlying diseases. For the large number of patients with chronic hepatitis B virus infection (CHB), studies on their immune responses to these vaccines are still lacking. MethodsA total of 57 CHB patients and 19 healthy controls (HCs) receiving inactivated influenza vaccination were prospectively followed up. Influenza-specific immunoglobulin G (IgG) antibodies (anti-H1N1, anti-H3N2, and anti-B IgG), antibody-secreting cells (ASCs), and circulating T follicular helper cells were assessed simultaneously. Eight CHB patients subsequently got inactivated SARS-CoV-2 vaccination during 1-year follow-up, and levels of serum antibodies against SARS-CoV-2 were further analyzed. ResultsOn day 28 after influenza vaccination, three influenza antibodies levels appeared to be lower in CHB patients than in HCs. And anti-H1N1 IgG level was significantly decreased in cirrhotic patients (p < .05). Anti-H1N1 IgG levels (day 28) were positively correlated with ASC frequencies (day 7) (p < .05), and negatively correlated with cirrhosis and hepatitis B surface antigen levels (p < .05). Anti-SARS-CoV-2 antibodies were higher in patients with influenza vaccination history than in patients without the history (p < .05). Moreover, positive correlations existed between influenza vaccination history and anti-SARS-CoV-2 antibody levels (p < .01). ConclusionsCHB patients, especially those with cirrhosis, appeared to have a decreased antibody response to inactivated influenza vaccine. A history of inactivated influenza vaccination within 1 year before inactivated SARS-CoV-2 vaccination might induce stronger anti-SARS-CoV-2 antibody response."

基金机构："National Science and Technology Major Project of China; National Natural Science Foundation of China; Natural Science Foundation of Chongqing, China; [2017ZX10202203-007]; [2017ZX10202203-008]; [2018ZX10302206-003]; [81772198]; [cstc2020jcyj-msxmX0389]"

基金资助正文："ACKNOWLEDGMENTS This work is supported by the National Science and Technology Major Project of China (2017ZX10202203-007, 2017ZX10202203-008, 2018ZX10302206-003). We also acknowledge the support of the National Natural Science Foundation of China (81772198), Natural Science Foundation of Chongqing, China (cstc2020jcyj-msxmX0389)."