Integrated bioinformatics-based identification of potential diagnostic biomarkers associated with atopic dermatitis

作者全名："Chen, Guanghua; Yan, Jia"

作者地址："[Chen, Guanghua] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Dermatol,Minist Educ Key Lab Child Dev & Diso, Chongqing, Peoples R China; [Yan, Jia] Chongqing Med Univ, Univ Town Hosp, Digest Dept, Chongqing, Peoples R China; [Yan, Jia] Chongqing Med Univ, Univ Town Hosp, Digest Dept, Chongqing 401331, Peoples R China"

通信作者："Yan, J (通讯作者)，Chongqing Med Univ, Univ Town Hosp, Digest Dept, Chongqing 401331, Peoples R China."

来源：POSTEPY DERMATOLOGII I ALERGOLOGII

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000905348500011

JCR分区：Q4

影响因子：1.4

年份：2022

卷号：39

期号：6

开始页：1059

结束页：1068

文献类型：Article

关键词：atopic dermatitis; GEO database; bioinformatics; hub genes; pathways

摘要："Introduction: In-depth analysis of the rambling genes of atopic dermatitis may help to identify the pathologic mechanism of this disease. However, this has seldom been performed. Aim: Using bioinformatics approaches, we analysed 3 gene expression profiles in the gene expression omnibus (GEO) database, identified the differentially expressed genes (DEGs), and found out the overlapping DEGs (common DEGs, cDEGs) in the above 3 profiles. Material and methods: We identified 91 upregulated cDEGs, which were then arranged into a protein-protein interaction (PPI) network, and Kyoto Encyclopaedia of Genes and Genomes (KEGG) pathway and Gene Ontology (GO) term enrichment analyses were performed to explore the functional roles of these genes. Results: GO analyses revealed these DEGs to be significantly enriched in biological processes including immune system process, immune response, defence response, leukocyte activation, and response to the biotic stimulus. These DEGs were also enriched in the KEGG pathway, including influenza A, amoebiasis, primary immunodeficiency, cytokine-cytokine receptor interaction, and IL-17 signalling pathway. PPI analysis showed that 9 genes (PTPRCCTLA4-CD274-CD1C-IL7R-GZMB-CCL5-CD83, and CCL22) were probably the novel hub genes of atopic dermatitis. Conclusions: Together, the findings of these bioinformatics analyses thus identified key hub genes associated with AD development."

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