A Calcium Alginate Hydrogel Microsphere-Based Transcatheter Arterial Viroembolization Strategy for Hepatocellular Carcinoma

作者全名："Lv, Peng; Chen, Hu; Cheng, Hongwei; Liu, Xuan; Liu, Chao; Zeng, Yun; Jiang, Lai; Wang, Xiaoyong; Mao, Jingsong; Liu, Gang"

作者地址："[Lv, Peng; Chen, Hu; Cheng, Hongwei; Liu, Xuan; Liu, Chao; Zeng, Yun; Jiang, Lai; Wang, Xiaoyong; Liu, Gang] Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China; [Lv, Peng; Chen, Hu; Cheng, Hongwei; Liu, Xuan; Liu, Chao; Zeng, Yun; Jiang, Lai; Wang, Xiaoyong; Liu, Gang] Xiamen Univ, Ctr Mol Imaging & Translat Med, Sch Publ Hlth, Xiamen 361102, Peoples R China; [Lv, Peng] Chongqing Med Univ, Key Lab Mol Biol Infect Dis Designated Chinese Min, Chongqing 400016, Peoples R China; [Mao, Jingsong] Xiamen Univ, Dept Radiol, Xiangan Hosp, Xiamen 361102, Peoples R China; [Mao, Jingsong] Amoy Hopeful Biotechnol Co Ltd, Xiamen 361027, Peoples R China"

通信作者："Liu, G (通讯作者)，Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, Xiamen 361102, Peoples R China.; Mao, JS (通讯作者)，Xiamen Univ, Dept Radiol, Xiangan Hosp, Xiamen 361102, Peoples R China.; Mao, JS (通讯作者)，Amoy Hopeful Biotechnol Co Ltd, Xiamen 361027, Peoples R China."

来源：ADVANCED THERAPEUTICS

ESI学科分类：　

WOS号：WOS:000906045100001

JCR分区：Q2

影响因子：3.7

年份：2023

卷号：6

期号：4

开始页：　

结束页：　

文献类型：Article

关键词：alginate gel microsphere; oncolytic adenoviruses; sustained released; transcatheter arterial viroembolization; virotherapy

摘要："Oncolytic adenoviruses (OAs)-based virotherapy can regulate the tumor microenvironment, providing a rational strategy for combination treatment with other tumor therapy techniques, such as transcatheter arterial embolization (TAE). Here, a novel, validated transcatheter arterial viroembolization (TAVE) strategy-a calcium alginate hydrogel microsphere with OA encapsulated (OA@Alg beads) to achieve a combination of TAE with oncolytic virotherapy to enhance and prolong antitumor efficacy of OA in hepatocellular carcinoma treatment-is described. The OA@Alg beads show excellent vascular embolization in a rabbit hepatic VX2 carcinoma model, resulting in successful occlusion of hepatic arteries. Importantly, OA@Alg beads enable sustained release of OA and maintain their bioactivity for extended periods while preventing OA shedding from the tumor site to healthy tissues. Moreover, the system preserves the OA's ability to induce an antitumor immune response, resulting in higher intratumoral infiltration by CD4(+)/CD8(+) T cells. The OA@Alg beads have the potential as an effective embolic system for TAVE in the clinical treatment of hepatocellular carcinoma."

基金机构："Major State Basic Research Development Program of China [2017YFA0205201]; National Natural Science Foundation of China (NSFC) [81603015, 81801817, 81901876, U1705281]; Fundamental Research Funds for the Central Universities [20720190088, 20720200019]; Science Foundation of Fujian Province [2020Y4003, 201812631010, JT180649, HXJB-08]; Program for New Century Excellent Talents in University, China [NCET-13-0502]"

基金资助正文："This work was supported by the Major State Basic Research Development Program of China (2017YFA0205201), the National Natural Science Foundation of China (NSFC) (81603015, 81801817, 81901876, and U1705281), the Fundamental Research Funds for the Central Universities (20720190088 and 20720200019), the Science Foundation of Fujian Province (2020Y4003, 201812631010, JT180649, and HXJB-08), and the Program for New Century Excellent Talents in University, China (NCET-13-0502)."