Respiratory tract infection of fatal severe human bocavirus 1 in a 13-month-old child: A case report and literature review

作者全名："Liao, Jing; Yang, Zhongying; He, Yu; Wei, Jianhua; Ren, Luo; Liu, Enmei; Zang, Na"

作者地址："[Liao, Jing; Yang, Zhongying; He, Yu; Wei, Jianhua; Ren, Luo; Liu, Enmei; Zang, Na] Chongqing Med Univ, Childrens Hosp, Dept Resp Med, Chongqing, Peoples R China"

通信作者："Zang, N (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Resp Med, Chongqing, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000906077200001

JCR分区：Q2

影响因子：2.6

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：human bocavirus 1; severe infection; children; respiratory; STAT1 variant

摘要："Human bocavirus 1 (HBoV1) belongs to the family Parvoviridae and it is acknowledged that HBoV1 is a respiratory pathogen. We report the case of a 13-month-old boy who presented with a cough, shortness of breath, and wheezing, and who eventually died of severe pneumonia and acute respiratory distress syndrome (ARDS). Metagenomics next-generation sequencing (mNGS) showed that HBoV1 was the only detected pathogen. The nasopharyngeal aspirate viral load was 2.08 x 10(10) copies/ml and the serum viral load was 2.37 x 10(5) copies/ml. The child was still oxygen deficient under mechanical ventilation. Chest imaging suggested diffuse lesions in both lungs, an injury caused by ARDS. In this case, the clinical symptoms and signs of the child, the high viral load, viremia, and the detection of mNGS in the tracheal aspirate all supported that HBoV1 could cause severe acute respiratory tract infection in children without other pathogen infections."

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