Gallic acid inhibits neuroinflammation and reduces neonatal hypoxic-ischemic brain damages

作者全名："Dong, Xiangjun; Luo, Shuyue; Hu, Dongjie; Cao, Ruixue; Wang, Qunxian; Meng, Zijun; Feng, Zijuan; Zhou, Weihui; Song, Weihong"

作者地址："[Dong, Xiangjun; Luo, Shuyue; Hu, Dongjie; Wang, Qunxian; Meng, Zijun; Feng, Zijuan; Zhou, Weihui; Song, Weihong] Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & Le, Minist Educ,Key Lab Child Dev & Disorders,China I, Chongqing, Peoples R China; [Cao, Ruixue; Song, Weihong] Wenzhou Med Univ, Inst Aging, Zhejiang Prov Clin Res Ctr Mental Disorders, Sch Mental Hlth,Key Lab Alzheimers Dis Zhejiang Pr, Wenzhou, Peoples R China; [Cao, Ruixue; Song, Weihong] Wenzhou Med Univ, Kangning Hosp, Affiliated Hosp 2, Wenzhou, Peoples R China; [Cao, Ruixue; Song, Weihong] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China; [Song, Weihong] Zhejiang Lab Regenerat Med Vis & Brain Hlth, Oujiang Lab, Wenzhou, Peoples R China"

通信作者："Zhou, WH; Song, WH (通讯作者)，Chongqing Med Univ, Childrens Hosp, Chongqing Key Lab Translat Med Res Cognit Dev & Le, Minist Educ,Key Lab Child Dev & Disorders,China I, Chongqing, Peoples R China.; Song, WH (通讯作者)，Wenzhou Med Univ, Inst Aging, Zhejiang Prov Clin Res Ctr Mental Disorders, Sch Mental Hlth,Key Lab Alzheimers Dis Zhejiang Pr, Wenzhou, Peoples R China.; Song, WH (通讯作者)，Wenzhou Med Univ, Kangning Hosp, Affiliated Hosp 2, Wenzhou, Peoples R China.; Song, WH (通讯作者)，Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.; Song, WH (通讯作者)，Zhejiang Lab Regenerat Med Vis & Brain Hlth, Oujiang Lab, Wenzhou, Peoples R China."

来源：FRONTIERS IN PEDIATRICS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000907531600001

JCR分区：Q2

影响因子：2.6

年份：2022

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：hypoxic-ischemic brain damage; gallic acid; neuroprotective effect; neuroinflammation; neuronal loss

摘要："Neuroinflammation is a leading cause of secondary neuronal injury in neonatal hypoxic-ischemic encephalopathy (HIE). Regulation of neuroinflammation may be beneficial for treatment of HIE and its secondary complications. Gallic acid (GA) has been shown to have anti-inflammatory and antioxidant effects. In this report we found that oxygen-glucose deprivation and/reoxygenation (OGD/R)-induced cell death, and the generation of excessive reactive oxygen species (ROS) and inflammatory cytokines by microglia were inhibited by GA treatment. Furthermore, GA treatment reduced neuroinflammation and neuronal loss, and alleviated motor and cognitive impairments in rats with hypoxic-ischemic brain damage (HIBD). Together, our results reveal that GA is an effective regulator of neuroinflammation and has potential as a pharmaceutical intervention for HIE therapy."

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