Increased Systemic Immune-Inflammation Index Predicts Disease Severity and Functional Outcome in Acute Ischemic Stroke Patients

作者全名："Huang, Lu"

作者地址："[Huang, Lu] Chongqing Med Univ, Dept Hlth Management Ctr, Affiliated Hosp 1, Chongqing, Peoples R China; [Huang, Lu] Chongqing Med Univ, Dept Hlth Management Ctr, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China"

通信作者："Huang, L (通讯作者)，Chongqing Med Univ, Dept Hlth Management Ctr, Affiliated Hosp 1, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：NEUROLOGIST

ESI学科分类：NEUROSCIENCE & BEHAVIOR

WOS号：WOS:000907905700006

JCR分区：Q4

影响因子：1.1

年份：2023

卷号：28

期号：1

开始页：32

结束页：38

文献类型：Article

关键词：acute ischemic stroke; systemic immune-inflammation index (SII); system inflammation response index (SIRI); severity of stroke; outcome

摘要："Background:Systemic immune-inflammation index (SII) and system inflammation response index (SIRI) have been recently investigated as novel inflammatory and prognostic markers. Our study aimed to investigate the relationship between SII and SIRI index and severity of stroke, and to analyze the prognostic value in acute ischemic stroke (AIS) patients. Methods:The SII is defined as plateletx(neutrophil count/lymphocyte count), SIRI is defined as neutrophil countx(monocyte count/lymphocyte count). We plotted receiver operating characteristic curves of SII and SIRI for poor outcomes and calculated area under the curve (AUC) values and cutoff values. Multivariate logistic regression analysis was performed to analyze the association between SII/SIRI index and poor functional outcome. Results:We included 234 AIS patients [mean age 69 (57-78) years; 50.4% male]. Both SII and SIRI were higher in the moderate-to-severe stroke group than in the mild stroke group [932.73 (569.84-1610.90) vs. 581.21 (386.98-1015.59), P<0.001 and 2.00 (1.24-3.13) vs. 1.35 (0.83-1.92), P <0.001]. The area under the receiver operating characteristic curve (area under the curve) value of SII (0.678, 0.608-0.748, P<0.001) tested a similar discriminatory ability compared with SIRI (0.682, 95% CI (0.612-0.751), P<0.001). Multivariate logistic regression analyses showed that SII was significantly associated with poor prognosis at discharge of AIS patients [adjusted odds ratio (95% confidence interval): 2.350 (1.149-4.803), P=0.019)], conversely, SIRI had no prognostic value. Conclusions:Higher SII and SIRI indexes were correlated with greater risk of stroke severity, meanwhile SII could be useful for predicting adverse clinical outcomes after AIS."

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