TBHP/KI-Promoted Oxidative Cyclization of alpha-Aminoketones for One-Pot Synthesis of Substituted 2-Acyloxazoles

作者全名："Zheng, Jiecheng; Zhu, Dali; Yang, Zhangyou; Chen, Huali; Wang, Wei; Gan, Lin Ling; Gan, Zongjie"

作者地址："[Zheng, Jiecheng; Zhu, Dali; Yang, Zhangyou; Chen, Huali; Gan, Zongjie] Chongqing Med Univ, Dept Med Chem, Coll Pharm, Chongqing 400016, Peoples R China; [Wang, Wei] Chongqing Fuling Inst Food & Drug Control, Chongqing 408102, Peoples R China; [Gan, Lin Ling] Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Sch Pharm, Chongqing 401331, Peoples R China"

通信作者："Gan, ZJ (通讯作者)，Chongqing Med Univ, Dept Med Chem, Coll Pharm, Chongqing 400016, Peoples R China.; Gan, LL (通讯作者)，Chongqing Med & Pharmaceut Coll, Chongqing Engn Res Ctr Pharmaceut Sci, Sch Pharm, Chongqing 401331, Peoples R China."

来源：SYNTHESIS-STUTTGART

ESI学科分类：CHEMISTRY

WOS号：WOS:000908387000002

JCR分区：Q2

影响因子：2.2

年份：2023

卷号：55

期号：9

开始页：1419

结束页：1426

文献类型：Article

关键词：metal-free; TBHP/KI; 2-acyloxazole; oxidative cyclization

摘要：A metal-free and facile synthesis of substituted 2-acyloxazole derivatives from alpha-aminoketones was developed via a TBHP/KI-promoted oxidative cyclization. This procedure proceeded smoothly under mild conditions and a broad scope of 2-acyloxazoles were obtained in moderate to good yields.

基金机构：National Natural Science Foundation of China; [21907013]

基金资助正文：We appreciate the finical support from the National Natural Science Foundation of China (No. 21907013).