Glucose levels affect MgaSpn regulation on the virulence and adaptability of Streptococcus pneumoniae

作者全名："Suo, Weicai; Guo, Xinlin; Zhang, Xuemei; Xiao, Shengnan; Wang, Shuhui; Yin, Yibing; Zheng, Yuqiang"

作者地址："[Suo, Weicai; Guo, Xinlin; Wang, Shuhui; Zheng, Yuqiang] Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Med Lab,Minist Educ,Key Lab Child Dev & Disor, Chongqing, Peoples R China; [Suo, Weicai; Guo, Xinlin; Wang, Shuhui; Zheng, Yuqiang] Chongqing Key Lab Pediat, Chongqing, Peoples R China; [Zhang, Xuemei; Yin, Yibing] Chongqing Med Univ, Key Lab Diagnost Med Designated, Minist Educ, Chongqing, Peoples R China; [Xiao, Shengnan] Chongqing Med Univ, Precis Med Ctr, Affiliated Hosp 2, Chongqing, Peoples R China"

通信作者："Zheng, YQ (通讯作者)，Chongqing Med Univ, Childrens Hosp, Natl Clin Res Ctr Child Hlth & Disorders, Dept Med Lab,Minist Educ,Key Lab Child Dev & Disor, Chongqing, Peoples R China.; Zheng, YQ (通讯作者)，Chongqing Key Lab Pediat, Chongqing, Peoples R China."

来源：MICROBIAL PATHOGENESIS

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000908389000001

JCR分区：Q2

影响因子：3.3

年份：2023

卷号：174

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Mga Spn; Glucose; Phosphorylcholine; Streptococcus pneumoniae; Adaptability

摘要："Streptococcus pneumoniae can regulate virulence gene expression by sensing environmental changes, which is key to its pathogenicity. The global transcription regulator MgaSpn of Streptococcus pneumoniae regulates virulence genes expression by directly binding to the promoter regions, but its role in response to different environments remains unclear. In this study, we found that glucose levels could affect phosphocholine content, which was mediated by MgaSpn. MgaSpn can also alter its anti-phagocytosis ability, depending on the availability of glucose. In addition, transcriptome analysis of wild-type D39s in low and high glucose concentrations revealed that MgaSpn was also involved in the regulation of carbon metabolism inhibition (carbon catabolite repression; CCR) and translation processes, which made S. pneumoniae highly competitive in fluctuating environments. In conclusion, MgaSpn is closely related to the virulence and environmental adaptability of Streptococcus pneumoniae."

基金机构："Projects of the National Natural Science Foundation of China [81871698, 81772153]"

基金资助正文：This work was supported by Projects of the National Natural Science Foundation of China (No.81871698 and No.81772153).