Risk Factors and Prognosis of Carbapenem-Resistant Organism Colonization and Infection in Acute Cholangitis

作者全名："Li, Kaili; Jiang, Sanle; Fu, Hongxue; Hao, Yingting; Tian, Shijing; Zhou, Fachun"

作者地址："[Li, Kaili; Jiang, Sanle; Fu, Hongxue; Hao, Yingting; Tian, Shijing; Zhou, Fachun] Chongqing Med Univ, Dept Crit Care Med, Affiliated Hosp 1, Chongqing, Peoples R China; [Tian, Shijing; Zhou, Fachun] Chongqing Med Univ, Emergency Dept, Affiliated Hosp 1, 1 Youyi Rd,17th Floor,Bldg 1, Chongqing, Peoples R China"

通信作者："Tian, SJ; Zhou, FC (通讯作者)，Chongqing Med Univ, Emergency Dept, Affiliated Hosp 1, 1 Youyi Rd,17th Floor,Bldg 1, Chongqing, Peoples R China."

来源：INFECTION AND DRUG RESISTANCE

ESI学科分类：IMMUNOLOGY

WOS号：WOS:000909774700001

JCR分区：Q2

影响因子：3.9

年份：2022

卷号：15

期号：　

开始页：7777

结束页：7787

文献类型：Article

关键词：CRO; acute cholangitis; risk factors; prognosis

摘要："Background: To identify the risk factors and prognosis of carbapenem-resistant organisms (CRO) in patients with acute cholangitis.Methods: This retrospective observational study was conducted to explore the risk factors and prognosis of CRO infection in 503 acute cholangitis patients diagnosed between July 2013 and January 2022 at the First Affiliated Hospital of Chongqing Medical University, who were divided into a CRO group and non-CRO group based on the presence or absence of CRO. Univariate, multivariate analyses, and the proportional hazards model were used to compare the risk factors and prognosis of CRO suffering in patients with acute cholangitis.Results: We identified 35 patients colonized with CRO from 503 acute cholangitis patients. In the multivariate analysis, tumor (OR=7.09, 95% CI=1.11-45.30, P=0.038) and chronic kidney disease (OR=8.70, 95% CI=2.11-35.88, P=0.003) were ascertained as the risk factors of the occurrence on CRO infection under the background of acute cholangitis. CRO infection was identified as an independent risk factor for acute cholangitis patient death (HR=5.147, 95% CI=1.475-17.595, P=0.01) by Cox proportional-hazards regression.Conclusion: Tumor and chronic kidney disease may be risk factors for CRO infection. Patients diagnosed with acute cholangitis further infected with CRO had a poor prognosis and a more severe mortality. Active screening for CRO is expected to facilitate early prevention, diagnosis, and treatment of high-risk patients."

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