"A Comprehensive Hepatitis B Surface Antigen-Positive Patient-Centered Screening and Linkage to Care Strategies Targeting Microelimination of Hepatitis C Virus Infection in Chongqing, China"

作者全名："Cai, Dachuan; Zhang, Dazhi; Hu, Peng; Ren, Hong"

作者地址："[Cai, Dachuan; Zhang, Dazhi; Hu, Peng; Ren, Hong] Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Chongqing, Peoples R China; [Cai, Dachuan; Zhang, Dazhi; Hu, Peng; Ren, Hong] Chongqing Med Univ, Inst Viral Hepatitis, Chongqing, Peoples R China; [Cai, Dachuan; Zhang, Dazhi; Hu, Peng; Ren, Hong] Minist Educ, Key Lab Mol Biol Infect Dis, Chongqing, Peoples R China"

通信作者："Ren, H (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Infect Dis, Chongqing, Peoples R China.; Ren, H (通讯作者)，Chongqing Med Univ, Inst Viral Hepatitis, Chongqing, Peoples R China.; Ren, H (通讯作者)，Minist Educ, Key Lab Mol Biol Infect Dis, Chongqing, Peoples R China."

来源：CANADIAN JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000910986500001

JCR分区：Q3

影响因子：2.7

年份：2022

卷号：2022

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Background and Aims. The likelihood of coinfection increases in regions where HBV is endemic because of the similar transmission route. China is another endemic nation, with 5.9% of the population being HBsAg-positive. This study aimed to evaluate the prevalence of HCV antibody positivity in HBsAg-positive subjects, HCV RNA positivity in anti-HCV positive subjects, and HBV/HCV coinfection with the hope of exploring hepatitis C microelimination using currently available therapies. Method. 12,500 HBsAg-positive serum samples were collected. All samples were screened for anti-HCV. Furthermore, positive samples were screened for HCV RNA. All patients with positive HCV RNA were followed up for suspicious transmission routes of HCV and linkage to care. Results. 44 out of 10,560 (0.4%) patients with positive HBsAg had detectable anti-HCV. There were 32 males and 12 females, with a statistical difference. 17 out of 44 were HCV RNA positive. Among them, 15 out of 38 patients were HCV RNA positive; 8 patients had started anti-HCV treatment with the DAA regimen, while the other 7 patients had not. After patient education, one patient had begun treatment and reached SVR12, while three patients still refused anti-HCV treatment. Conclusion. The HCV/HBV coinfection prevalence was found to be lower in this study. Even though HBV and HCV share a somewhat similar transmission route, HBsAg-positive subjects may not be at high risk for HCV infection. The process of hepatitis C's microelimination could be accelerated by increasing patient awareness and education."

基金机构："Gilead Sciences, Inc. [IN-US-987-5364]; Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2022ZDXM001]"

基金资助正文："This study is supported by Gilead Sciences, Inc. (IN-US-987-5364) and Chongqing medical scientific research project (Joint project of Chongqing Health Commission and Science and Technology Bureau) [2022ZDXM001]."