Systemic antibiotics increase microbiota pathogenicity and oral bone loss

作者全名："Yuan, Xulei; Zhou, Fuyuan; Wang, He; Xu, Xinxin; Xu, Shihan; Zhang, Chuangwei; Zhang, Yanan; Lu, Miao; Zhang, Yang; Zhou, Mengjiao; Li, Han; Zhang, Ximu; Zhang, Tingwei; Song, Jinlin"

作者地址："[Yuan, Xulei; Zhou, Fuyuan; Wang, He; Xu, Xinxin; Xu, Shihan; Zhang, Chuangwei; Zhang, Yanan; Lu, Miao; Zhang, Yang; Zhou, Mengjiao; Li, Han; Zhang, Ximu; Zhang, Tingwei; Song, Jinlin] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing, Peoples R China"

通信作者："Zhang, TW; Song, JL (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing, Peoples R China."

来源：INTERNATIONAL JOURNAL OF ORAL SCIENCE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000913298000001

JCR分区：Q1

影响因子：10.8

年份：2023

卷号：15

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：　

摘要："Periodontitis is the most widespread oral disease and is closely related to the oral microbiota. The oral microbiota is adversely affected by some pharmacologic treatments. Systemic antibiotics are widely used for infectious diseases but can lead to gut dysbiosis, causing negative effects on the human body. Whether systemic antibiotic-induced gut dysbiosis can affect the oral microbiota or even periodontitis has not yet been addressed. In this research, mice were exposed to drinking water containing a cocktail of four antibiotics to explore how systemic antibiotics affect microbiota pathogenicity and oral bone loss. The results demonstrated, for the first time, that gut dysbiosis caused by long-term use of antibiotics can disturb the oral microbiota and aggravate periodontitis. Moreover, the expression of cytokines related to Th17 was increased while transcription factors and cytokines related to Treg were decreased in the periodontal tissue. Fecal microbiota transplantation with normal mice feces restored the gut microbiota and barrier, decreased the pathogenicity of the oral microbiota, reversed the Th17/Treg imbalance in periodontal tissue, and alleviated alveolar bone loss. This study highlights the potential adverse effects of long-term systemic antibiotics-induced gut dysbiosis on the oral microbiota and periodontitis. A Th17/Treg imbalance might be related to this relationship. Importantly, these results reveal that the periodontal condition of patients should be assessed regularly when using systemic antibiotics in clinical practice."

基金机构："National Natural Science Foundation of China [31971282, U22A20314, 82170968]; 2019 Chongqing Graduate Tutor Team Construction Project [dstd201903]; National Key R&D of Program of China [2022YFC2504200]"

基金资助正文："This research was supported by grants 31971282, U22A20314 (to J.S.), 82170968 (to T.Z.) from the National Natural Science Foundation of China. This research was also supported by dstd201903 (to J.S.) from the 2019 Chongqing Graduate Tutor Team Construction Project and 2022YFC2504200 (to J.S.) from National Key R&D of Program of China."