YAP/TAZ axis was involved in the effects of metformin on breast cancer

作者全名："Xu, Yu; Cai, Hongke; Xiong, Yuanfeng; Tang, Li; Li, Longjiang; Zhang, Li; Shen, Yi; Yang, Yongqiang; Lin, Ling; Huang, Jiayi"

作者地址："[Xu, Yu; Xiong, Yuanfeng; Tang, Li; Li, Longjiang; Zhang, Li; Shen, Yi; Yang, Yongqiang; Lin, Ling; Huang, Jiayi] Chongqing Med Univ, Coll Basic Med Sci, Dept Pathophysiol, 1 Med Coll Rd, Chongqing 400016, Peoples R China; [Cai, Hongke] Chongqing Med Univ, Affiliated Hosp 2, Dept Gastrointestinal Surg, Chongqing, Peoples R China"

通信作者："Huang, JY (通讯作者)，Chongqing Med Univ, Coll Basic Med Sci, Dept Pathophysiol, 1 Med Coll Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF CHEMOTHERAPY

ESI学科分类：PHARMACOLOGY & TOXICOLOGY

WOS号：WOS:000913854000001

JCR分区：Q3

影响因子：1.9

年份：2023

卷号：　

期号：　

开始页：　

结束页：　

文献类型：Article; Early Access

关键词：Metformin; breast cancer; YAP; TAZ activity; hippo signalling pathway; nuclear translocation; novel drug; epithelial-mesenchymal transition

摘要："Breast cancer is malignant tumours in women. A large amount of data analysis shows that Metformin has been shown to play a significance role in reducing the risk of breast cancer, but the mechanism remains unclear. The hippo signalling pathway can be involved in the formation, metastasis and recurrence of breast cancer. When YAP/TAZ is activated, cells can overcome contact inhibition and enter a state of uncontrolled proliferation. Therefore, YAP/TAZ is considered a potential therapeutic target for breast cancer. Eighty breast cancer patients, forty cases of triple-negative and forty cases of HER-2+, were included in this study. In vitro and in vivo experiments were used to confirm the YAP/TAZ axis was involved in the effects of metformin on breast cancer. EMT plays an important role in breast cancer, including chemoresistance and tumour metastasis. Our results confirmed that YAP could modulate the activity of EMT, which in turn altered tumour resistance. Therefore, MET can inhibit EMT by reducing the expression of YAP, and finally achieve the therapeutic effect of breast cancer. Our findings support metformin as a novel YAP inhibitor and potentially as a novel breast cancer drug."

基金机构：Chongqing Science and Technology Commission [cstc2018jscx-msybX0053]; Kuanren Talents Program of the Second Affiliate Hospital of Chongqing Medical University [kryc-gg-2112]

基金资助正文：This study was funded by Chongqing Science and Technology Commission [grant no. cstc2018jscx-msybX0053] and Kuanren Talents Program of the Second Affiliate Hospital of Chongqing Medical University [grant no. kryc-gg-2112].