NIR Activated Multimodal Therapeutics Based on Metal-Phenolic Networks-Functionalized Nanoplatform for Combating against Multidrug Resistance and Metastasis

作者全名："Cheng, Chen; Jiang, Weixi; Luo, Yuanli; Wan, Li; Guo, Xun; Xie, Zhuoyan; Tang, Rui; Huang, Tong; Wang, Jingxue; Du, Chier; Wang, Zhigang; Ran, Haitao; Li, Pan; Zhou, Zhiyi; Ren, Jianli"

作者地址："[Cheng, Chen; Jiang, Weixi; Luo, Yuanli; Wan, Li; Guo, Xun; Xie, Zhuoyan; Tang, Rui; Huang, Tong; Wang, Jingxue; Du, Chier; Wang, Zhigang; Ran, Haitao; Li, Pan; Zhou, Zhiyi; Ren, Jianli] Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Cheng, Chen; Jiang, Weixi; Luo, Yuanli; Wan, Li; Guo, Xun; Xie, Zhuoyan; Tang, Rui; Huang, Tong; Wang, Jingxue; Du, Chier; Wang, Zhigang; Ran, Haitao; Li, Pan; Zhou, Zhiyi; Ren, Jianli] Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Cheng, Chen] Chongqing Med Univ, Bishan Hosp Chongqing, Dept Ultrasound, Bishan Hosp, Chongqing 402760, Peoples R China; [Zhou, Zhiyi] Chongqing Gen Hosp, Dept Gen Practice, Chongqing 401147, Peoples R China"

通信作者："Zhou, ZY; Ren, JL (通讯作者)，Chongqing Med Univ, Dept Ultrasound, Affiliated Hosp 2, Chongqing 400010, Peoples R China.; Zhou, ZY; Ren, JL (通讯作者)，Chongqing Med Univ, Chongqing Key Lab Ultrasound Mol Imaging, Affiliated Hosp 2, Chongqing 400010, Peoples R China."

来源：SMALL

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000914779200001

JCR分区：Q1

影响因子：13

年份：2023

卷号：19

期号：14

开始页：　

结束页：　

文献类型：Article

关键词：chemosensitization; controlled drug release; immunotherapy; multidrug resistance; near-infrared irradiation

摘要："Multidrug resistance (MDR) and metastasis in cancer have become increasingly serious problems since antitumor efficiency is greatly restricted by a single therapeutic modality and the insensitive tumor microenvironment (TME). Herein, metal-phenolic network-functionalized nanoparticles (t-P@ TFP NPs) are designed to realize multiple therapeutic modalities and reshape the TME from insensitive to sensitive under multimodal imaging monitoring. After a single irradiation, a near-infrared laser-activated multistage reaction occurs. t-P@TFP NPs trigger the phase transition of perfluoropentane (PFP) to release tannic acid (TA)/ferric ion (Fe3+)-coated paclitaxel (PTX) and cause hyperthermia in the tumor region to efficiently kill cancer cells. Additionally, PTX is released after the disassembly of the TA-Fe3+ film by the abundant adenosine triphosphate (ATP) in the malignant tumor, which concurrently inhibits ATP-dependent drug efflux to improve sensitivity to chemotherapeutic agents. Furthermore, hyperthermia-induced immunogenic cell death (ICD) transforms ""cold"" tumors into ""hot"" tumors with the assistance of PD-1/PD-L1 blockade to evoke antitumor immunogenicity. This work carefully reveals the mechanisms underlying the abilities of these multifunctional NPs, providing new insights into combating the proliferation and metastasis of multidrug-resistant tumors."

基金机构："National Natural Science Foundation of China [82171946, 81873901]; Basic Research and Frontier Exploration Key Project of Chongqing Science and Technology Commission [cstc2019jcyj-zdxmX0020]; Senior Medical Talents Program of Chongqing for Young and Middle-aged, CQMU Program for Youth Innovation in Future Medicine [W0026]; Chongqing Science and Health Joint Medical Research Project-Young and Middle-aged High-level Talent Project [2020GDRC011]; Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University [KR2019G001]"

基金资助正文："C.C., W.J., and Y.L. contributed equally to this work. This study was financially supported by the National Natural Science Foundation of China (Grant No. 82171946, 81873901), Basic Research and Frontier Exploration Key Project of Chongqing Science and Technology Commission (Grant No. cstc2019jcyj-zdxmX0020), Senior Medical Talents Program of Chongqing for Young and Middle-aged, CQMU Program for Youth Innovation in Future Medicine (W0026), Chongqing Science and Health Joint Medical Research Project-Young and Middle-aged High-level Talent Project (2020GDRC011), and Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University (KR2019G001)."