Prognostic value of interleukin-34 and interleukin-38 in patients with newly diagnosed atrial fibrillation

作者全名："Ma, Jiaxue; Wu, Na; Yuan, Zhiquan; Chen, Yanxiu; Li, Chengying; Xie, Weijia; Zhang, Zhihui; Li, Yafei; Zhong, Li"

作者地址："[Ma, Jiaxue; Zhong, Li] Chongqing Med Univ, Affiliated Hosp 3, Cardiovasc Dis Ctr, Chongqing, Peoples R China; [Wu, Na; Yuan, Zhiquan; Li, Chengying; Xie, Weijia; Li, Yafei] Army Med Univ, Coll Prevent Med, Dept Epidemiol, Chongqing, Peoples R China; [Wu, Na; Yuan, Zhiquan; Li, Chengying; Xie, Weijia; Li, Yafei] Army Med Univ, Evidence based Med & Clin Epidemiol Ctr, Chongqing, Peoples R China; [Chen, Yanxiu; Zhang, Zhihui] Army Med Univ, Southwest Hosp, Ctr Circadian Metab & Cardiovasc Dis, Dept Cardiol, Chongqing, Peoples R China"

通信作者："Zhong, L (通讯作者)，Chongqing Med Univ, Affiliated Hosp 3, Cardiovasc Dis Ctr, Chongqing, Peoples R China.; Li, YF (通讯作者)，Army Med Univ, Coll Prevent Med, Dept Epidemiol, Chongqing, Peoples R China.; Li, YF (通讯作者)，Army Med Univ, Evidence based Med & Clin Epidemiol Ctr, Chongqing, Peoples R China.; Zhang, ZH (通讯作者)，Army Med Univ, Southwest Hosp, Ctr Circadian Metab & Cardiovasc Dis, Dept Cardiol, Chongqing, Peoples R China."

来源：FRONTIERS IN CARDIOVASCULAR MEDICINE

ESI学科分类：　

WOS号：WOS:000916776000001

JCR分区：Q2

影响因子：2.8

年份：2023

卷号：9

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：interleukins; prognosis; CHA2DS2-VASc score; ABC score; atrial fibrillation

摘要："BackgroundInterleukin (IL)-34 and IL-38 are associated with cardiovascular disease (CVD). However, their involvement in atrial fibrillation (AF) and AF-associated adverse events remains uncertain. Therefore, we aimed to investigate their association with various AF prognostic factors in a cohort study and assessed their predictive value for the prognosis of patients with AF. MethodsPatients with new-onset non-valvular AF were consecutively enrolled between 2013 and 2015 at the Department of Cardiovascular Medicine of the Southwest Hospital of the Army Medical University (Third Military Medical University) in Chongqing, China. The endpoints included stroke and all-cause mortality. The baseline levels of plasma IL-34, IL-38, NT-proBNP, high-sensitivity cardiac troponin T (hs-cTnT), and GDF-15 were measured and their correlation with AF-related adverse events were analyzed in a Cox proportional-hazards regression model. The C-statistic, net reclassification improvement (NRI), and integrated discrimination improvement (IDI) were used to evaluate the performance of the AF prognostic models. Decision curve analysis (DCA) was used to evaluate the clinical net benefit of the original and modified models. ResultsA total of 299 patients with new-onset AF were enrolled. During the median follow-up time of 28 (IQR: 27, 29) months, the higher levels of IL-34 were associated with a lower risk of stroke, and the higher levels of IL-38 were associated with an increased risk of all-cause death (all adjusted P < 0.05). In addition, elevated hs-cTnT and NT-proBNP concentrations were associated with a higher risk of stroke and all-cause mortality (all adjusted P < 0.05). Furthermore, the CHA(2)DS(2)-VASc score combined with IL-38 and NT-proBNP significantly improved the C-statistic, IDI, and NRI (all P < 0.01). There was no statistically significant difference (all P > 0.05) in the discrimination power between the preference models and the ABC (age, biomarkers, and clinical history) score for the two prognostic outcomes. ConclusionOur results suggested that IL-34 and IL-38 were independently associated with stroke and all-cause mortality in patients with AF. Moreover, adding IL-38 and NT-proBNP to the CHA(2)DS(2)-VASc score significantly improved its predictive ability of AF-related all-cause death. Finally, the preference model performed equally well as the ABC score in predicting AF prognosis."

基金机构：National Natural Science Foundation of China [82073649]

基金资助正文：Funding This work was supported by the National Natural Science Foundation of China (No. 82073649 to NW).