Multiple statistical models reveal specific volatile organic compounds affect sex hormones in American adult male: NHANES 2013-2016

作者全名："Wei, Chengcheng; Cao, Li; Zhou, Yuancheng; Zhang, Wenting; Zhang, Pu; Wang, Miao; Xiong, Ming; Deng, Changqi; Xiong, Qi; Liu, Weihui; He, Qingliu; Guo, Yihong; Shao, Zengwu; Chen, Xiaogang; Chen, Zhaohui"

作者地址："[Wei, Chengcheng; Zhou, Yuancheng; Zhang, Pu; Wang, Miao; Xiong, Ming; Deng, Changqi; Chen, Zhaohui] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, Wuhan, Hubei, Peoples R China; [Cao, Li; Shao, Zengwu] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China; [Zhang, Wenting] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Obstet & Gynecol, Wuhan, Hubei, Peoples R China; [Xiong, Qi] Chongqing Med Univ, Chongqing, Peoples R China; [Liu, Weihui; He, Qingliu; Guo, Yihong] Fujian Med Univ, Dept Urol, Affiliated Hosp 2, Quanzhou, Peoples R China; [Chen, Xiaogang] Hubei Polytech Univ, Huangshi Cent Hosp, Dept Urol, Affliated Hosp, Huangshi, Peoples R China"

通信作者："Chen, ZH (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, Wuhan, Hubei, Peoples R China.; Shao, ZW (通讯作者)，Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Orthopaed, Wuhan, Hubei, Peoples R China.; He, QL; Guo, YH (通讯作者)，Fujian Med Univ, Dept Urol, Affiliated Hosp 2, Quanzhou, Peoples R China.; Chen, XG (通讯作者)，Hubei Polytech Univ, Huangshi Cent Hosp, Dept Urol, Affliated Hosp, Huangshi, Peoples R China."

来源：FRONTIERS IN ENDOCRINOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000917906800001

JCR分区：Q2

影响因子：3.9

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：volatile organic compounds (VOCs); testosterone (TT); estradiol (E2); SHBG; machine learning

摘要："BackgroundSome VOCs are identified as endocrine-disrupting chemicals (EDCs), interfering with the effect of sex hormones. However, no studies focused on the common spectrum of environmental VOCs exposure affecting sex hormones in the average male population. ObjectivesWe aimed to explore the association between VOCs and sex hormones in American adult males using multiple statistical models. MethodsThe generalized linear (GLM), eXtreme Gradient Boosting (XGBoost), weighted quantile sum (WQS), Bayesian kernel machine regression (BKMR) and stratified models were used to evaluate the associations between Specific Volatile Organic Compounds and sex hormones in American adult male from NHANES 2013-2016. ResultsPearson correlation model revealed the potential co-exposure pattern among VOCs. XGBoost algorithm models and the WQS model suggested the relative importance of VOCs. BKMR models reveal that co-exposure to the VOCs was associated with increased Testosterone (TT), Estradiol (E-2), SHBG and decreased TT/E-2. GLM models revealed specific VOC exposure as an independent risk factor causing male sex hormones disorders. Stratified analysis identified the high-risk group on the VOCs exposures. We found Blood 2,5-Dimethylfuran in VOCs was the most significant effect on sex hormones in male. Testosterone increased by 213.594 (ng/dL) (124.552, 302.636) and estradiol increased by 7.229 (pg/mL) for each additional unit of blood 2,5-Dimethylfuran (ng/mL). ConclusionThis study is an academic illustration of the association between VOCs exposure and sex hormones, suggesting that exposure to VOCs might be associated with sex hormone metabolic disorder in American adult males."

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