Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities

作者全名："Liu, Dahai; Li, Jie; Qi, Fei; You, Hua"

作者地址："[Liu, Dahai; Li, Jie] Foshan Univ, Sch Med, Foshan, Guangdong, Peoples R China; [Qi, Fei] Peking Univ Shenzhen Hosp, Dept Pulm & Crit Care Med, Shenzhen, Peoples R China; [You, Hua] Chongqing Med Univ, Childrens Hosp, Dept Pediat Hematol & Oncol, Chongqing, Peoples R China; [You, Hua] Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Lab Excellence Syst Biomed Pediat Oncol, Chongqing Key Lab Pediat,Minist Educ Key Lab Chi, Chongqing, Peoples R China"

通信作者："You, H (通讯作者)，Chongqing Med Univ, Childrens Hosp, Dept Pediat Hematol & Oncol, Chongqing, Peoples R China.; You, H (通讯作者)，Childrens Hosp Chongqing Med Univ, Natl Clin Res Ctr Child Hlth & Disorders, Lab Excellence Syst Biomed Pediat Oncol, Chongqing Key Lab Pediat,Minist Educ Key Lab Chi, Chongqing, Peoples R China."

来源：FRONTIERS IN ONCOLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000918548700001

JCR分区：Q2

影响因子：3.5

年份：2023

卷号：12

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：pancreatic cancer; semaphorins; mechanisms; Sema3; Sema4D

摘要："Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low cure rate, and expensive related testing cost. Therefore, the significance of finding new markers for PC is self-evident. Semaphorins (Semas) have been shown to affect angiogenesis and lymphangiogenesis and can also directly affect the behavior of tumor cells. The expression and related action targets of its family members on PC are summarized in this review."

基金机构："National Natural Science Foundation of China [81911530169]; Natural Science Foundation of Guangdong Province of China [2022A1515011368]; Key Projects of Department of Education of Guangdong Province of China [2022ZDZX2057, 2022ZXKC474]"

基金资助正文："Funding The work in the Liu Lab is supported by The National Natural Science Foundation of China (Grant No. 82270413, 81870307), The Natural Science Foundation of Guangdong Province of China (Grant No. 2022A1515011368), and The Key Projects of Department of Education of Guangdong Province of China (Grant No. 2022ZDZX2057, 2022ZXKC474). The work in the You Lab is supported by The National Natural Science Foundation of China (Grant No. 81911530169)."