A HAase/NIR responsive surface on titanium implants for treating bacterial infection and improving osseointegration

作者全名："Li, Dan; Wang, Danyang; He, Ye; Tao, Bailong; Liu, Xiaoxia; Yang, Yulu; Tan, Lu; Zhang, Yuchen; Hu, Jingwei; Yang, Weihu; Tang, Yu; Cai, Kaiyong"

作者地址："[Li, Dan; Wang, Danyang; He, Ye; Liu, Xiaoxia; Yang, Yulu; Tan, Lu; Hu, Jingwei; Yang, Weihu; Cai, Kaiyong] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China; [Tao, Bailong] Chongqing Med Univ, Lab Res Ctr, Affiliated Hosp 1, Chongqing 400016, Peoples R China; [Zhang, Yuchen] Chongqing Univ, Sch Life Sci, Chongqing 400044, Peoples R China; [Tang, Yu] Army Med Univ, Affiliated Xinqiao Hosp 2, Dept Orthoped, Chongqing 400030, Peoples R China"

通信作者："Yang, WH; Cai, KY (通讯作者)，Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.; Tang, Y (通讯作者)，Army Med Univ, Affiliated Xinqiao Hosp 2, Dept Orthoped, Chongqing 400030, Peoples R China."

来源：JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY

ESI学科分类：MATERIALS SCIENCE

WOS号：WOS:000918845700004

JCR分区：Q1

影响因子：11.2

年份：2023

卷号：143

期号：　

开始页：93

结束页：106

文献类型：Article

关键词：Titanium implant; Antibiosis; Hyaluronidase response; Mesoporous polydopamine nanoparticles

摘要："Bacterial infection and insufficient osseointegration are critical factors affecting the long-term success of titanium-based implants. Unfortunately, the direct application of antibiotic on Ti implants easily leads to poor cytocompatibility, as well as the production of drug-resistant bacteria. So, in this work, we designed a prospective antibacterial strategy by combining photothermal and ciprofloxacin (CIP). The synergistic effect of photothermal and antibiotic may provide an effective bacteriostatic efficacy without sacrificing osteogenesis at a mild condition of moderate temperature and less antibiotic. Herein, CIP was loaded into mesoporous polydopamine (MPDA) nanoparticles (MPDA@CIP), which were anchored on the surface of titanium and finally covered with sodium hyaluronate-catechol (HAc) coating. The hydrophilic HAc layer could inhibit the early adhesion of bacteria, and some bacteria could secrete bacterial hyaluronidase to accelerate the degradation of HAc. This enabled smart enzyme-triggered release of antimicrobials at the site of infection on-demand and avoided unwanted side effects on normal tissues. In addition, NIR light irradiation had a positive influence on both CIP release and MPDA nanoparticle's photothermal effect. Moreover, before anchoring MPDA@CIP, by the construction of hydroxyapatite microstructure on Ti sur-face with micro-arc oxidation and alkali heat treatment, the ability of bone formation of Ti could be promoted also. Both in vitro as well as in vivo assays demonstrated that functional Ti has an excellent antibacterial effect and osteogenic ability.(c) 2022 Published by Elsevier Ltd on behalf of The editorial office of Journal of Materials Science & Technology."

基金机构：National Natu- ral Science Foundation of China; Natural Science Foundation of Chongqing; [32071334]; [51825302]; [21734002]; [cstc2021jcyj-cxttX0 0 02]; [cstc2019jscx-msxmX0160]

基金资助正文："Acknowledgements This work was financially supported by the National Natu- ral Science Foundation of China (Nos. 32071334 , 51825302 and 21734002) , the Natural Science Foundation of Chongqing (Nos. cstc2021jcyj-cxttX0 0 02 and cstc2019jscx-msxmX0160) ."