Clinical characteristics and related influencing factors of common rheumatic diseases concomitant with tuberculosis

作者全名："Tang, Guo; Chen, Xixi; Han, Yaxin; Peng, Qing; Liu, Jiajun; Liu, Yan; Guo, Hongmei; Wu, Xiaodan; Liu, Jian; Zhou, Qiao; Long, Li"

作者地址："[Tang, Guo] Bishan Hosp Chongqing Med Univ, Dept Nephrol, Chongqing, Peoples R China; [Tang, Guo; Chen, Xixi; Han, Yaxin; Peng, Qing; Liu, Jiajun; Liu, Yan; Guo, Hongmei; Wu, Xiaodan; Liu, Jian; Zhou, Qiao; Long, Li] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Rheumatol & Immunol, Chengdu, Peoples R China; [Chen, Xixi; Wu, Xiaodan; Liu, Jian; Zhou, Qiao; Long, Li] Chinese Acad Sci Sichuan Translat Med Res Hosp, Dept Rheumatol & Immunol, Chengdu, Peoples R China; [Han, Yaxin] Peoples Hosp WenJiang, Dept Rheumatol & Immunol, Chengdu, Peoples R China; [Peng, Qing] Chengdu Second Peoples Hosp, Dept Rheumatol & Immunol, Chengdu, Peoples R China; [Liu, Jiajun; Liu, Yan] Zunyi Med Univ, Clin Med Coll 1, Dept Nephrol & Rheumatol, Zunyi, Guizhou, Peoples R China; [Guo, Hongmei] Univ Elect Sci & Technol China, Clin Med Coll, Dept Rheumatol & Immunol, Chengdu, Peoples R China"

通信作者："Zhou, Q; Long, L (通讯作者)，Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Rheumatol & Immunol, Chengdu, Peoples R China.; Zhou, Q; Long, L (通讯作者)，Chinese Acad Sci Sichuan Translat Med Res Hosp, Dept Rheumatol & Immunol, Chengdu, Peoples R China."

来源：FRONTIERS IN PUBLIC HEALTH

ESI学科分类：SOCIAL SCIENCES, GENERAL

WOS号：WOS:000919207500001

JCR分区：Q2

影响因子：3

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：clinical characteristics; rheumatic diseases; tuberculosis; concomitant; tuberculin skin test; interferon gamma release assay

摘要："ObjectiveTo explore the clinical characteristics and risk factors of common systemic rheumatism concomitant with tuberculosis (TB). MethodsA total of 3,906 patients of RA, SLE, and SS diagnosed in the People's Hospital of Sichuan Province from January 2007 to January 2017 were collected. One hundred and five patients with TB were included as TB group, including 42 RA, 41 SLE, and 22 SS patients. In the non-TB group, 84 RA, 82 SLE, and 44 SS patients were randomly selected during the same period. ResultsFever was the most common symptom among RA, SLE, and SS patients with TB, accounting for 83.3%, 92.7%, and 68.2%, respectively. Cough, weight loss or fatigue were the next common. RA patients with TB were mostly pulmonary TB (PTB), accounting for 64.3%. The proportion of PTB for SLE and SS were 46.3%, 59.01%, respectively. In TB group, 59% RA, 57% SLE, and 62% SS with PTB had two or more chest CT findings. There were 48 TB cases received both Interferon Gamma Release Assay (IGRA) and Tuberculin skin test (TST) with positive rates of 91.8%, 45.8%, respectively. The daily average dose of glucocorticoids within 1 year in TB group was higher than that in non-TB group of SLE patients, lower counts of CD4+ T cell count were found in TB group (P < 0.05), while no such differences were found in RA and SS patients. ConclusionRA patients with TB are mainly pulmonary TB. For SLE and SS patients, the chance of PTB and extrapulmonary tuberculosis is similar. Daily average dose of glucocorticoids within 1 year may be a common risk factor for RA, SLE and SS patients developing TB. Decreased CD4+ T cell count may also be a risk factor for SLE patients with TB. Symptoms of RA, SLE, SS with TB, are similar with the primary disease or other infection. It is recommended to conduct both TST and IGRA to help diagnose TB."

基金机构：Foundation of Sichuan Science and Technology Bureau [2020JDRC0118]

基金资助正文：Funding This research was supported by the Foundation of Sichuan Science and Technology Bureau (2020JDRC0118).