"The incidence, risk factors, characteristics, and prognosis of recurrent deep venous thrombosis in the contralateral lower extremity"

作者全名："Chen, Yushi; Tang, Bo; Nie, Menglin; Qi, Xiaotong; Wang, Fei; Wang, Haiyang"

作者地址："[Chen, Yushi] Chongqing Med Univ, Affiliated Hosp 2, Dept Clin Nutr, Chongqing, Peoples R China; [Tang, Bo; Nie, Menglin; Qi, Xiaotong; Wang, Fei; Wang, Haiyang] Chongqing Med Univ, Affiliated Hosp 2, Dept Abdominal Wall Hernia & Vasc Surg, 76 Linjiang Rd, Chongqing 400000, Peoples R China"

通信作者："Wang, HY (通讯作者)，Chongqing Med Univ, Affiliated Hosp 2, Dept Abdominal Wall Hernia & Vasc Surg, 76 Linjiang Rd, Chongqing 400000, Peoples R China."

来源：JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000919353700008

JCR分区：Q1

影响因子：2.8

年份：2023

卷号：11

期号：1

开始页：52

结束页：60

文献类型：Article

关键词：Contralateral; Prognosis; Recurrent deep venous thrombosis; Risk factor

摘要："Background: Recurrent events after a first symptomatic deep venous thrombosis (DVT) are relatively frequent, but little is known about contralateral recurrent DVT (RDVT). Methods: We retrospectively reviewed the medical records of patients with a first symptomatic lower extremity DVT between January 2017 and April 2021. The incidence, demographics, risk factors, and prognosis of RDVT were analyzed, with differences compared between patients with contralateral RDVT and those with ipsilateral RDVT. Results: In 570 consecutive patients with DVT, 28 patients (4.91%) developed contralateral RDVT, and 49 patients (8.60%) developed ipsilateral RDVT during a mean follow-up of 27.62 6 14.84 months. Contralateral RDVT was more frequently found in the right lower extremity, whereas ipsilateral RDVT had more left lower extremity involvement. The median follow-up was 12 months until ipsilateral RDVT and 26.5 months until contralateral RDVT. In multivariate Cox analysis, inherited thrombophilia, stent extension with 50% to 100% coverage, autoimmune disease and anticoagulation noncompliance were identified as risk factors for contralateral RDVT. During follow-up, 5 patients (17.86%) with contralateral RDVT and 10 patients (20.41%) with ipsilateral RDVT died (P > .05), with 12 of 15 dying of an underlying malignancy. Conclusions: The incidence of contralateral RDVT after a first symptomatic DVT is relatively low, and contralateral DVT is strongly associated with stent extension with 50% to 100% coverage, autoimmune disease, anticoagulation noncom-pliance, and inherited thrombophilia. Compared with ipsilateral RDVT, contralateral RDVT occurs later and is more often in the right lower extremity. Survival following contralateral RDVT is similar to survival following ipsilateral RDVT, with underlying malignancy being the leading cause of death."

基金机构：Chongqing Medical Scientific Research Project (Chongqing Health Commission) [2020FYYX194]; Chongqing Medical Scientific Research Project (Science and Technology Bureau) [2020FYYX194]

基金资助正文：This work was supported by the Chongqing Medical Scientific Research Project (Joint Project of Chongqing Health Commission and Science and Technology Bureau; 2020FYYX194) .