Modulatory effects of mesenchymal stem cells on microglia in ischemic stroke

作者全名："Hao, Lei; Yang, Yongtao; Xu, Xiaoli; Guo, Xiuming; Zhan, Qunling"

作者地址："[Hao, Lei] Chongqing Med Univ, Dept Neurol, Branch 1, Affiliated Hosp 1, Chongqing, Peoples R China; [Hao, Lei; Guo, Xiuming] Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China; [Hao, Lei; Yang, Yongtao; Xu, Xiaoli; Zhan, Qunling] Fifth Peoples Hosp Chongqing, Dept Neurol, Chongqing, Peoples R China"

通信作者："Guo, XM (通讯作者)，Chongqing Med Univ, Dept Neurol, Affiliated Hosp 1, Chongqing, Peoples R China.; Zhan, QL (通讯作者)，Fifth Peoples Hosp Chongqing, Dept Neurol, Chongqing, Peoples R China."

来源：FRONTIERS IN NEUROLOGY

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000919993000001

JCR分区：Q2

影响因子：2.7

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Review

关键词：mesenchymal stem cell; extracellular vesicles; microglia; ischemic stroke; cell polarization

摘要："Ischemic stroke accounts for 70-80% of all stroke cases. Immunity plays an important role in the pathophysiology of ischemic stroke. Microglia are the first line of defense in the central nervous system. Microglial functions are largely dependent on their pro-inflammatory (M1-like) or anti-inflammatory (M2-like) phenotype. Modulating neuroinflammation via targeting microglia polarization toward anti-inflammatory phenotype might be a novel treatment for ischemic stroke. Mesenchymal stem cells (MSC) and MSC-derived extracellular vesicles (MSC-EVs) have been demonstrated to modulate microglia activation and phenotype polarization. In this review, we summarize the physiological characteristics and functions of microglia in the healthy brain, the activation and polarization of microglia in stroke brain, the effects of MSC/MSC-EVs on the activation of MSC in vitro and in vivo, and possible underlying mechanisms, providing evidence for a possible novel therapeutics for the treatment of ischemic stroke."

基金机构：General Program of Chongqing Natural Science Foundation [cstc2020jcyj-msxmX0988]

基金资助正文：Funding This study was funded by the General Program of Chongqing Natural Science Foundation (cstc2020jcyj-msxmX0988).