Genome-wide allele and haplotype-sharing patterns suggested one unique Hmong-Mein-related lineage and biological adaptation history in Southwest China

作者全名："Wang, Jiawen; Yang, Lin; Duan, Shuhan; Sun, Qiuxia; Li, Youjing; Wu, Jun; Wu, Wenxin; Wang, Zheng; Liu, Yan; Tang, Renkuan; Yang, Junbao; Liu, Chao; Yuan, Buhong; Wang, Daoyong; Xu, Jianwei; Wang, Mengge; He, Guanglin"

作者地址："[Liu, Yan; He, Guanglin] Sichuan Univ, West China Hosp, Inst Rare Dis, Chengdu 610041, Peoples R China; [Wang, Jiawen; Yang, Lin; Wu, Jun; Wu, Wenxin] Guizhou Med Univ, Coll Forens Med, Guiyang 550004, Peoples R China; [Duan, Shuhan; Liu, Yan; Yang, Junbao] North Sichuan Med Coll, Sch Basic Med Sci, Nanchong 637000, Peoples R China; [Sun, Qiuxia; Tang, Renkuan] Chongqing Med Univ, Coll Basic Med, Dept Forens Med, Chongqing 400331, Peoples R China; [Li, Youjing] Congjiang Peoples Hosp, Congjiang 557499, Peoples R China; [Xu, Jianwei] Guizhou Med Univ, Sch Basic Med, Dept Pharmacol, Guiyang 550004, Peoples R China; [Liu, Chao; Wang, Mengge] Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou 510275, Peoples R China; [Wang, Zheng] Sichuan Univ, West China Sch Basic Med Sci & Forens Med, Inst Forens Med, Chengdu 610000, Peoples R China; [Yuan, Buhong] Longli Peoples Hosp, Longli 551299, Peoples R China; [Wang, Daoyong] Nayong Guohua Yixin Hosp, Nayong 553306, Peoples R China"

通信作者："He, GL (通讯作者)，Sichuan Univ, West China Hosp, Inst Rare Dis, Chengdu 610041, Peoples R China.; Xu, JW (通讯作者)，Guizhou Med Univ, Sch Basic Med, Dept Pharmacol, Guiyang 550004, Peoples R China.; Wang, MG (通讯作者)，Sun Yat Sen Univ, Fac Forens Med, Zhongshan Sch Med, Guangzhou 510275, Peoples R China."

来源：HUMAN GENOMICS

ESI学科分类：MOLECULAR BIOLOGY & GENETICS

WOS号：WOS:000920040500001

JCR分区：Q2

影响因子：3.8

年份：2023

卷号：17

期号：1

开始页：　

结束页：　

文献类型：Article

关键词：Genetic structure; Evolutionary history; Miao; Admixture model; Biological adaptation

摘要："BackgroundFine-scale genetic structure of ethnolinguistically diverse Chinese populations can fill the gap in the missing diversity and evolutionary landscape of East Asians, particularly for anthropologically informed Chinese minorities. Hmong-Mien (HM) people were one of the most significant indigenous populations in South China and Southeast Asia, which were suggested to be the descendants of the ancient Yangtze rice farmers based on linguistic and archeological evidence. However, their deep population history and biological adaptative features remained to be fully characterized.ObjectivesTo explore the evolutionary and adaptive characteristics of the Miao people, we genotyped genome-wide SNP data in Guizhou HM-speaking populations and merged it with modern and ancient reference populations via a comprehensive population genetic analysis and evolutionary admixture modeling.ResultsThe overall genetic admixture landscape of Guizhou Miao showed genetic differentiation between them and other linguistically diverse Guizhou populations. Admixture models further confirmed that Miao people derived their primary ancestry from geographically close Guangxi Gaohuahua people. The estimated identity by descent and effective population size confirmed a plausible population bottleneck, contributing to their unique genetic diversity and population structure patterns. We finally identified several natural selection candidate genes associated with several biological pathways.ConclusionsGuizhou Miao possessed a specific genetic structure and harbored a close genetic relationship with geographically close southern Chinese indigenous populations and Guangxi historical people. Miao people derived their major ancestry from geographically close Guangxi Gaohuahua people and experienced a plausible population bottleneck which contributed to the unique pattern of their genetic diversity and structure. Future ancient DNA from Shijiahe and Qujialing will provide new insights into the origin of the Miao people."

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