"Antimicrobial resistance profile of methicillin-resistant Staphylococcus aureus isolates in children reported from the ISPED surveillance of bacterial resistance, 2016-2021"

作者全名："Wu, Xia; Wang, Chuanqing; He, Leiyan; Xu, Hongmei; Jing, Chunmei; Chen, Yinghu; Lin, Aiwei; Deng, Jikui; Cao, Qing; Deng, Huiling; Cai, Huijun; Chen, Yiping; Yang, Jinhong; Zhang, Ting; Huang, Yuanyuan; Hao, Jianhua; Yu, Hui"

作者地址："[Wu, Xia; Yu, Hui] Fudan Univ, Dept Infect Dis, Childrens Hosp, Shanghai, Peoples R China; [Wang, Chuanqing; He, Leiyan] Fudan Univ, Childrens Hosp, Dept Clin Lab, Shanghai, Peoples R China; [Xu, Hongmei] Chongqing Med Univ, Childrens Hosp, Dept Infect Dis, Chongqing, Peoples R China; [Jing, Chunmei] Chongqing Med Univ, Childrens Hosp, Dept Clin Lab, Chongqing, Peoples R China; [Chen, Yinghu] Zhejiang Univ, Childrens Hosp, Sch Med, Dept Infect Dis, Hangzhou, Peoples R China; [Lin, Aiwei] Shandong Univ, Qilu Childrens Hosp, Dept Infect Dis, Jinan, Peoples R China; [Deng, Jikui] Shenzhen Childrens Hosp, Dept Infect Dis, Shenzhen, Peoples R China; [Cao, Qing] Shanghai Jiao Tong Univ, Shanghai Childrens Med Ctr, Sch Med, Dept Infect Dis, Shanghai, Peoples R China; [Deng, Huiling] Xian Childrens Hosp, Dept Infect Dis, Xian, Peoples R China; [Cai, Huijun] Xian Childrens Hosp, Dept Clin Lab, Xian, Peoples R China; [Chen, Yiping] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Pediat Infect Dis, Wenzhou, Peoples R China; [Yang, Jinhong] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Clin Lab, Wenzhou, Peoples R China; [Zhang, Ting] Shanghai Jiao Tong Univ, Sch Med, Dept Gastroenterol & Infect Dis, Childrens Hosp, Shanghai, Peoples R China; [Huang, Yuanyuan] Bethune First Hosp Jilin Univ, Dept Pediat, Changchun, Peoples R China; [Hao, Jianhua] Kaifeng Childrens Hosp, Dept Infect Dis, Kaifeng, Peoples R China"

通信作者："Yu, H (通讯作者)，Fudan Univ, Dept Infect Dis, Childrens Hosp, Shanghai, Peoples R China."

来源：FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY

ESI学科分类：MICROBIOLOGY

WOS号：WOS:000921773100001

JCR分区：Q1

影响因子：4.6

年份：2023

卷号：13

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：methicillin-resistant Staphylococcus aureus; antimicrobial resistance; children; infectious disease surveillance of pediatrics (ISPED); neonates

摘要："IntroductionMethicillin-resistant Staphylococcus aureus (MRSA) poses a serious threat to public health worldwide. In December 2015, the Infectious Disease Surveillance of Pediatrics (ISPED) program was organized to monitor bacterial epidemiology and resistance trends in children. MethodsThis retrospective study was conducted from January 2016-December 2021 on patients at eleven ISPED-group hospitals. ResultsFrom 2016-2021, a total of 13024 MRSA isolates were obtained from children. The most common age group for patients with MRSA infection was less than 3 years old, and newborns were an important group affected by MRSA infection. MRSA was most commonly isolated from the lower respiratory, an abscess, a secretion, or blood in neonates and from the lower respiratory, an abscess, or the upper respiratory in non-neonates. All isolates were susceptible to vancomycin and linezolid and resistant to penicillin; additionally, 76.88%, 54.97%, 22.30%, 5.67%, 5.14%, 3.63%, and 1.42% were resistant to erythromycin, clindamycin, tetracycline, levofloxacin, sulfamethoxazole-trimethoprim (TMP-SMX), gentamicin, and rifampin, respectively. Between 2016 and 2021, a significant increase was seen in the levofloxacin- and TMP-SMX-resistance rates (from 5.45% to 7.14% and from 4.67% to 6.50%, respectively) among MRSA isolates, along with a significant decrease in the rates of resistance to erythromycin (from 82.61% to 68.08%), clindamycin (from 60.95% to 46.82%), tetracycline (from 25.37% to 17.13%), gentamicin (from 4.53% to 2.82%), and rifampin (from 1.89% to 0.41%). DiscussionThe antibiotic-resistance rates varied among MRSA isolated from different sources. Because of the high antibiotic resistance rate to clindamycin, this antibiotic is not recommended for empirical treatment of MRSA infections, especially in osteomyelitis."

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