Nutrient-sensing nanoprotoplast augments tumor accumulation and immune response with short-term starvation

作者全名："Cao, Guoliang; Tan, Mixiao; Huang, Wenping; Zhang, Jie; Yin, Yue; Li, Xiaoyang; Ma, Haixia; Su, Wen; Li, Suping; Ran, Haitao; Ho, Shih-Hsin; Wang, Hai"

作者地址："[Cao, Guoliang; Huang, Wenping; Zhang, Jie; Yin, Yue; Li, Xiaoyang; Ma, Haixia; Su, Wen; Li, Suping; Wang, Hai] Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China; [Cao, Guoliang; Ho, Shih-Hsin] Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150040, Peoples R China; [Tan, Mixiao; Ran, Haitao] Chongqing Med Univ, Affiliated Hosp 2, Chongqing 400010, Peoples R China; [Tan, Mixiao; Ran, Haitao] Chongqing Key Lab Ultrasound Mol Imaging, Chongqing 400010, Peoples R China; [Wang, Hai] Univ Chinese Acad Sci, Beijing 100049, Peoples R China"

通信作者："Wang, H (通讯作者)，Natl Ctr Nanosci & Technol, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China.; Ho, SH (通讯作者)，Harbin Inst Technol, State Key Lab Urban Water Resource & Environm, Harbin 150040, Peoples R China."

来源：NANO TODAY

ESI学科分类：PHYSICS

WOS号：WOS:000922218400001

JCR分区：Q1

影响因子：13.2

年份：2023

卷号：49

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Tumor nutrient metabolism; Nanoprotoplast; Antitumor immunity; Cancer therapy

摘要："Many efforts have been devoted to improve delivery efficiency of nanocarriers in tumor site. However, current strategies are mainly focusing on regulating the materials rather than the biological system. We here demonstrate that short-term starvation (STS) can enhance the cellular uptake and tumor accumulation of nanocarriers. Tumor cells can assimilate a significant amount of extracellular massive necrotic cell debris vesicles (NCDVs) and built more blood vessels after STS treatment. We thereby developed a NCDVs-mi-micking nanoprotoplast using bacterial protoplast. This NCDVs-mimicking nanoprotoplast can efficiently accumulate at tumor site and inhibit type 1 or 2 insulin-like growth factor receptor (IGF-1R or IGF-2R, respectively) mediated cell proliferation by reducing IGF-1 with STS treatment and delivering inhibitors. Moreover, this nanoprotoplast can trigger the immune response and be further augmented with STS treatment. Collectively, STS treatment can not only improve the cellular uptake and tumor accumulation of NCDVs-mimicking nanoprotoplast, but also strengthen the antitumor immunity of the nanoprotoplast.(c) 2023 Elsevier Ltd. All rights reserved."

基金机构：Strategic Priority Research Program of Chinese Academy of Sciences [XDB36000000]; NSFC [31971307]; Start-up Foundation of National Center for Nanoscience and Technology

基金资助正文："Acknowledgements This work was financially supported by the Strategic Priority Research Program of Chinese Academy of Sciences (XDB36000000) , NSFC (31971307) , and the Start-up Foundation of National Center for Nanoscience and Technology."