A modified method for constructing experimental rat periodontitis model

作者全名："Zhang, Xuyang; Xu, Minglu; Xue, Qin; He, Yao"

作者地址："[Zhang, Xuyang; Xu, Minglu; Xue, Qin; He, Yao] Chongqing Med Univ, Dept Orthodont, Stomatol Hosp, Chongqing, Peoples R China; [Zhang, Xuyang; Xu, Minglu; Xue, Qin] Chongqing Med Univ, Chongqing Key Lab Oral Dis & Biomed Sci, Stomatol Hosp, Chongqing, Peoples R China; [He, Yao] Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing, Peoples R China"

通信作者："He, Y (通讯作者)，Chongqing Med Univ, Dept Orthodont, Stomatol Hosp, Chongqing, Peoples R China.; He, Y (通讯作者)，Chongqing Med Univ, Chongqing Municipal Key Lab Oral Biomed Engn Highe, Stomatol Hosp, Chongqing, Peoples R China."

来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ESI学科分类：Multidisciplinary

WOS号：WOS:000922346500001

JCR分区：Q1

影响因子：4.3

年份：2023

卷号：10

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：periodontitis; rat model; bone loss; animal model; inflammation

摘要："Background: Periodontitis is a prevalent disease caused teeth lost. The present rat models inducing periodontitis with thread ligature and metal steel ligature have some disadvantages.Methods: We modified the existing rat ligature periodontitis model by fixing the thread ligature on the metal steel ligature passed through the gap between the first and second molars of rats with detailed modeling steps and illustrations. We research the pathological process of the periodontitis induced by the modified model, and briefly compared the modified model with the thread ligature model and the metal steel ligature model.Result: Our experimental results showed that there was an aggravation in inflammatory infiltration and alveolar bone resorption in modeling area within 14 days of initial induction. After that, the inflammatory infiltration was reduced. And no significant increase in alveolar bone destruction appeared. The modified model was more reliable compared to the thread ligature model, and had greater ability of bacterial aggregation compared to the metal steel ligature model.Conclusion: The modified method covered pathological process of the periodontitis, and showed sufficient efficiency and reliability in inducing rat periodontitis."

基金机构：China Postdoctoral Science Foundation [2018M640902]

基金资助正文：This work was supported by China Postdoctoral Science Foundation (2018M640902 to YH).