Sustained intra-articular reactive oxygen species scavenging and alleviation of osteoarthritis by biocompatible amino-modified tantalum nanoparticles

作者全名："Jiang, Yunsheng; Li, Tao; Yang, Junjun; Wang, Xin; Song, Xiongbo; Chen, Guangxing; Dai, Gang; Li, Rong; Yao, Chunyan; Chen, Jiajia; Chen, Cheng; Gong, Xiaoyuan; Yang, Liu"

作者地址："[Jiang, Yunsheng; Li, Tao; Yang, Junjun; Wang, Xin; Song, Xiongbo; Chen, Guangxing; Dai, Gang; Gong, Xiaoyuan; Yang, Liu] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China; [Li, Tao; Li, Rong] Army Med Univ, Mil Med Univ 3, Inst Combined Injury, Coll Prevent Med,State Key Lab Trauma Burns & Comb, Chongqing, Peoples R China; [Yang, Junjun] Chongqing Univ, Minist Educ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Chongqing, Peoples R China; [Yao, Chunyan] Army Med Univ, Mil Med Univ 3, Southwest Hosp, Blood Transfus Dept, Chongqing, Peoples R China; [Chen, Jiajia] Army Med Univ, Mil Med Univ 3, Biomed Anal Ctr, Chongqing, Peoples R China; [Chen, Cheng] Chongqing Med Univ, Coll Med Informat, Chongqing, Peoples R China"

通信作者："Gong, XY; Yang, L (通讯作者)，Army Med Univ, Mil Med Univ 3, Southwest Hosp, Ctr Joint Surg, Chongqing, Peoples R China."

来源：FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY

ESI学科分类：Multidisciplinary

WOS号：WOS:000922836000001

JCR分区：Q1

影响因子：4.3

年份：2023

卷号：11

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：tantalum nanoparticles; catalase activity; ROS scavenging agent; oxidative stress; osteoarthritis

摘要："Recent studies highlight the vital role of oxidative stress and reactive oxygen species (ROS) during progression of osteoarthritis (OA). Attenuating oxidative stress and reducing reactive oxygen species generation in joints represent reasonable strategies for the treatment of osteoarthritis. To address the potential question for clinical translation, and improve the biocompatibility and long-term performance of current antioxidants, the present study provided high biocompatible small positively charged tantalum nanoparticles (Ta-NH2 NPs) with sustained intra-articular catalase activity and first applied to osteoarthritis intervention. Our in vitro results showed that Ta-NH2 NPs were stable with good biocompatibility, and protected viability and hyaline-like phenotype in H2O2-challenged chondrocytes. In addition, the in vivo biodistribution data demonstrated a sustained retention of Ta-NH2 NPs in the joint cavity, particularly in articular cartilage without organ toxicity and abnormality in hemogram or blood biochemistry indexes. Finally, compared with catalase (CAT), Ta-NH2 NPs exhibited long-term therapeutic effect in monosodium iodoacetate (MIA) induced osteoarthritis model. This study preliminarily explored the potential of simply modified metal nanoparticles as effective reactive oxygen species scavenging agent for osteoarthritis intervention, and offered a novel strategy to achieve sustained reactive oxygen species suppression using biocompatible Ta-based nano-medicine in oxidative stress related diseases."

基金机构：Chongqing Talent Project [CQYC20210101319]; Nature Science Foundation of Chongqing [cstc2021jcyj-msxmX0135]

基金资助正文："This research was funded by Chongqing Talent Project (CQYC20210101319), Nature Science Foundation of Chongqing (cstc2021jcyj-msxmX0135)."