Impact of Thyroid Function on the Prevalence and Mortality of Metabolic Dysfunction-Associated Fatty Liver Disease

作者全名："Chen, Yu-ling; Tian, Shen; Wu, Juan; Li, Hao; Li, Shu; Xu, Zhou; Liang, Xin-yu; Adhikari, Vishnu Prasad; Xiao, Jun; Song, Jing-yu; Ma, Chen-yu; She, Rui-ling; Li, Zhao-xing; Wu, Kai-nan; Kong, Ling-quan"

作者地址："[Chen, Yu-ling; Tian, Shen; Wu, Juan; Li, Hao; Li, Shu; Xu, Zhou; Liang, Xin-yu; Xiao, Jun; Song, Jing-yu; Ma, Chen-yu; She, Rui-ling; Li, Zhao-xing; Wu, Kai-nan; Kong, Ling-quan] Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China; [Xu, Zhou] North Sichuan Med Coll, Affiliated Hosp, Dept Thyroid & Breast Surg, Nanchong 637000, Sichuan, Peoples R China; [Adhikari, Vishnu Prasad] Zhejiang Univ, Affiliated Hosp 1, Dept Hepatobiliary & Pancreat Surg, Hangzhou 310003, Peoples R China; [Xiao, Jun] Peoples Hosp Linshui Cty, Dept Gen Surg, Linshui 638500, Sichuan, Peoples R China"

通信作者："Kong, LQ (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Dept Endocrine & Breast Surg, 1 Youyi Rd, Chongqing 400016, Peoples R China."

来源：JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000924775800001

JCR分区：Q1

影响因子：5

年份：2023

卷号：　

期号：　

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结束页：　

文献类型：Article; Early Access

关键词：MAFLD; subclinical hypothyroidism; low thyroid function; TSH; mortality

摘要："Context Thyroid function variation within the thyroxine reference range has negative metabolic effects. Metabolic dysfunction-associated fatty liver disease (MAFLD) is a recently proposed definition. Objective We aim to explore the effects of thyroid function status on prevalence and mortality of MAFLD. Methods Data of 10 666 participants from the Third National Health and Nutrition Examination Survey (NHANES III) were used. MAFLD was diagnosed based on the new definition. Thyroid function variation within the thyroxine reference range was defined based on thyroid-stimulating hormone (TSH) levels: subclinical hyperthyroidism, <0.39 mIU/L; strict-normal thyroid function, 0.39-2.5 mIU/L; and low thyroid function, >2.5 mIU/L, which comprised low-normal thyroid function (2.5-4.5 mIU/L) and subclinical hypothyroidism (> 4.5 mIU/L). Logistic and Cox regression were used in multivariate analysis. Results Low thyroid function is independently associated with MAFLD (odds ratio: 1.27). Compared with strict-normal thyroid function, subclinical hypothyroidism was significantly associated with increased risk for all-cause and cardiovascular mortality in the total population (hazard ratio [HR] for all-cause: 1.23; cardiovascular: 1.65) and MAFLD population (HR for all-cause: 1.32; cardiovascular: 1.99); meanwhile, in the low-normal thyroid function group, an increasing trend in mortality risk was observed. Furthermore, low thyroid function also showed significant negative impact on mortality in the total and MAFLD population. Among thyroid function spectrum, mild subclinical hypothyroidism showed the highest HRs on mortality. Conclusions Low thyroid function is independent risk factor of MAFLD and is associated with increased risk for all-cause and cardiovascular mortality in the MAFLD population. Reevaluation of TSH reference range should be considered."

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