Association of Long Non-coding RNA C1RL-AS1 and PTPN6 Gene Polymorphisms with Ocular Behcet's Disease in Han Chinese

作者全名:"Wang, Xiaotang; Zhang, Qi; Hou, Shengping; Qi, Jian; Du, Liping; Li, Fuzhen; Cao, Qingfeng; Yang, Peizeng"

作者地址:"[Wang, Xiaotang; Zhang, Qi; Hou, Shengping; Qi, Jian; Cao, Qingfeng; Yang, Peizeng] First Affiliated Hosp Chongqing Med Univ, Chongqing Eye Inst, Chongqing Key Lab Ophthalmol, Chongqing Branch,Municipal Div,Natl Clin Res Ctr O, Chongqing, Peoples R China; [Du, Liping; Li, Fuzhen] First Affiliated Hosp Zhengzhou Univ, Henan Prov Eye Hosp, Dept Ophthalmol, Henan Int Joint Res Lab Ocular Immunol & Retinal I, Zhengzhou, Peoples R China; [Yang, Peizeng] First Affiliated Hosp Chongqing Med Univ, Chongqing Eye Inst, Chongqing Key Lab Ophthalmol, Chongqing Branch,Municipal Div,Natl Clin Res Ctr O, Chongqing 400016, Peoples R China"

通信作者:"Yang, PZ (通讯作者),First Affiliated Hosp Chongqing Med Univ, Chongqing Eye Inst, Chongqing Key Lab Ophthalmol, Chongqing Branch,Municipal Div,Natl Clin Res Ctr O, Chongqing 400016, Peoples R China."

来源:OCULAR IMMUNOLOGY AND INFLAMMATION

ESI学科分类:CLINICAL MEDICINE

WOS号:WOS:000924837900001

JCR分区:Q2

影响因子:2.6

年份:2023

卷号: 

期号: 

开始页: 

结束页: 

文献类型:Article; Early Access

关键词:Behcet's disease; genetic polymorphism; LncRNA; PTPN6

摘要:"PurposeTo explore the association of the polymorphisms in PTPN6 and LncRNA C1RL-AS1 genes with ocular BD in Han Chinese patients.MethodsCorrelation study was performed using the iPLEX system on a cohort of ocular BD patients andcontrols. The genotyping of 7 SNPs for LncRNA C1RL-AS1 and PTPN6 genes in ocular BD patients was performed using the iPLEX Gold genotype.ResultsThe frequencies of rs4013722 AG genotype/A allele in LncRNA C1RL-AS1 were significantly decreased in BD patients, and the frequency of GG genotype was significantly increased in BD patients. The rs4013722 was associated with ocular BD in male patients, but not in female patients. The AG and GG genotype of rs4013722 were associated with skin lesions in male patients. The gene polymorphisms of PTPN6 were not associated with BD patients.ConclusionsThe LncRNA C1RL-AS1/rs4013722 polymorphism conferred susceptibility to ocular BD in Han Chinese patients, which was influenced by sex."

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