Hangover headache and its behavioral changes in rats

作者全名:"Lu, Shiguang; Zhang, Ying; Yang, Yuejun; Zhang, Yafang; Qin, Guangcheng; Fu, Qingqing; Shi, Yingying; Zhang, Fan; Wang, Zhe; Chen, Yanhe; Liu, Yuancai; Chen, Lixue"

作者地址:"[Qin, Guangcheng; Fu, Qingqing; Chen, Lixue] Hubei Prov Key Lab Qual & Safety Tradit Chinese Me, Hubei, Peoples R China; [Qin, Guangcheng; Fu, Qingqing; Chen, Lixue] First Affiliated Hosp Chongqing Med Univ, Lab Res Ctr, Chongqing, Peoples R China; [Liu, Yuancai] Hubei Prov Key Lab Qual & Safety Tradit Chinese Me, Hubei, Peoples R China; [Chen, Lixue] First Affiliated Hosp Chongqing Med Univ, Lab Res Ctr, Chongqing, Peoples R China"

通信作者:"Liu, YC (通讯作者),Hubei Prov Key Lab Qual & Safety Tradit Chinese Me, Hubei, Peoples R China.; Chen, LX (通讯作者),First Affiliated Hosp Chongqing Med Univ, Lab Res Ctr, Chongqing, Peoples R China."

来源:IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES

ESI学科分类:PHARMACOLOGY & TOXICOLOGY

WOS号:WOS:000926195700005

JCR分区:Q3

影响因子:2.1

年份:2023

卷号:26

期号:3

开始页:326

结束页:334

文献类型:Article

关键词:Alcohol; Animal; Behavior; Central nervous system; sensitization; Disease models; Hangover; Headche

摘要:"Objective(s): The present study aims to establish and evaluate a rat model for hangover headaches caused by alcoholic drinks.Materials and Methods: Chronic migraine (CM) model rats were divided into 3 groups, and intragastrically administered alcoholic drinks (sample A, B, or C) to simulate hangover headache attacks. The withdrawal threshold for the hind paw/face and the thermal latency of hind paw withdrawal were detected after 24 hr. Serum was collected from the periorbital venous plexus of rats in each group, and enzymatic immunoassays were used to determine the serum levels of calcitonin gene-related peptide (CGRP), substance P (SP), and nitric oxide (NO).Results: Compared with the control group, the mechanical hind paw pain threshold was significantly lower in rats administered Samples A and B after 24 hr; however, no significant difference was observed across groups for the thermal pain threshold. The mechanical threshold for periorbital pain was only significantly reduced in rats administered Sample A. Immunoassays further indicated that serum levels of SP in the group administered Sample A were significantly higher than those in the control group; the serum levels of NO and CGRP were significantly higher in the group of rats receiving Sample B.Conclusion: We successfully developed an effective and safe rat model for investigating alcohol drink induced hangover headaches. This model could be used to investigate the mechanisms associated with hangover headaches for the development of novel and promising candidates for the future treatment or prophylaxis of hangover headaches."

基金机构:"Science Foundation of China Jingbrand CO, Ltd [X1-2249]"

基金资助正文:"This study was supported by the Science Foundation of China Jingbrand CO, Ltd (No. X1-2249) , the authors thank Jing barand CO, Ltd for providing financial support. The results presented in this paper were part of a student thesis."