Endothelial Glycocalyx in Aging and Age-related Diseases

作者全名："Sun, Lina; Wang, Lingyan; Ye, Kaisy Xinhong; Wang, Shoushi; Zhang, Rui; Juan, Zhaodong; Feng, Lei; Min, Su"

作者地址："[Sun, Lina; Wang, Lingyan; Wang, Shoushi; Zhang, Rui; Juan, Zhaodong] Weifang Med Univ, Sch Anesthesiol, Weifang, Peoples R China; [Sun, Lina; Min, Su] Chongqing Med Univ, Dept Anesthesiol, Affiliated Hosp 1, Chongqing, Peoples R China; [Ye, Kaisy Xinhong; Feng, Lei] Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore; [Min, Su] Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China"

通信作者："Feng, L (通讯作者)，Natl Univ Singapore, Yong Loo Lin Sch Med, Singapore, Singapore.; Min, S (通讯作者)，Chongqing Med Univ, Affiliated Hosp 1, Chongqing, Peoples R China."

来源：AGING AND DISEASE

ESI学科分类：CLINICAL MEDICINE

WOS号：WOS:000927287000001

JCR分区：Q1

影响因子：7

年份：2023

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期号：　

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文献类型：Review; Early Access

关键词：endothelial glycocalyx; aging; age-related diseases; healthy; older adults

摘要："The worldwide population is aging exponentially, creating burdens to patients, their families and society. Increasing age is associated with higher risk of a wide range of chronic diseases, and aging of the vascular system is closely linked to the development of many age-related diseases. Endothelial glycocalyx is a layer of proteoglycan polymers on the surface of the inner lumen of blood vessels. It plays an important role in maintaining vascular homeostasis and protecting various organ functions. Endothelial glycocalyx loss happens through the aging process and repairing the endothelial glycocalyx may alleviate the symptoms of age-related diseases. Given the important role of the glycocalyx and its regenerative properties, it is posited that the endothelial glycocalyx may be a potential therapeutic target for aging and age-related diseases and repairing endothelial glycocalyx could play a role in the promotion of healthy aging and longevity. Here, we review the composition, function, shedding, and manifestation of the endothelial glycocalyx in aging and age-related diseases, as well as regeneration of endothelial glycocalyx."

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