Minimally invasive electrochemical continuous glucose monitoring sensors: Recent progress and perspective

作者全名："Zou, Yuanyuan; Chu, Zhengkang; Guo, Jiuchuan; Liu, Shan; Ma, Xing; Guo, Jinhong"

作者地址："[Guo, Jiuchuan; Guo, Jinhong] Univ Elect Sci & Technol China, Chengdu 611731, Peoples R China; [Chu, Zhengkang; Guo, Jinhong] Chongqing Med Univ, Chongqing 400016, Peoples R China; [Chu, Zhengkang] Shanghai Jiao Tong Univ, Sch Sensing Sci & Engn, Shanghai, Peoples R China; [Ma, Xing] Harbin Inst Technol Shenzhen, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China; [Liu, Shan] Univ Elect Sci & Technol, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Lab Med, Chengdu 610072, Peoples R China"

通信作者："Guo, JH (通讯作者)，Chongqing Med Univ, Chongqing 400016, Peoples R China.; Ma, X (通讯作者)，Harbin Inst Technol Shenzhen, Sch Mat Sci & Engn, Shenzhen 518055, Peoples R China.; Liu, S (通讯作者)，Univ Elect Sci & Technol, Sichuan Acad Med Sci & Sichuan Prov Peoples Hosp, Dept Lab Med, Chengdu 610072, Peoples R China."

来源：BIOSENSORS & BIOELECTRONICS

ESI学科分类：CHEMISTRY

WOS号：WOS:000927439100001

JCR分区：Q1

影响因子：10.7

年份：2023

卷号：225

期号：　

开始页：　

结束页：　

文献类型：Article

关键词：Continuous glucose monitoring; Invasiveness; Enzyme immobilization; Biocompatible membranes; Calibration; Prediction

摘要："Diabetes and its complications are seriously threatening the health and well-being of hundreds of millions of people. Glucose levels are essential indicators of the health conditions of diabetics. Over the past decade, concerted efforts in various fields have led to significant advances in glucose monitoring technology. In particular, the rapid development of continuous glucose monitoring (CGM) based on electrochemical sensing principles has great potential to overcome the limitations of self-monitoring blood glucose (SMBG) in continuously tracking glucose trends, evaluating diabetes treatment options, and improving the quality of life of diabetics. However, the applications of minimally invasive electrochemical CGM sensors are still limited owing to the following aspects: i) invasiveness, ii) short lifespan, iii) biocompatibility, and iv) calibration and prediction. In recent years, the performance of minimally invasive electrochemical CGM systems (CGMSs) has been significantly improved owing to breakthrough developments in new materials and key technologies. In this review, we summarize the history of commercial CGMSs, the development of sensing principles, and the research progress of minimally invasive electrochemical CGM sensors in reducing the invasiveness of implanted probes, maintaining enzyme activity, and improving the biocompatibility of the sensor interface. In addition, this review also introduces calibration algorithms and prediction algorithms applied to CGMSs and describes the application of machine learning algorithms for glucose prediction."

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